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山东脐血库保存4000人份脐血资料的统计分析
引用本文:潘杰,周胜利,沈柏均,阎文瑛,旭日,宋道刚. 山东脐血库保存4000人份脐血资料的统计分析[J]. 中国实验血液学杂志, 2002, 10(3): 257-260
作者姓名:潘杰  周胜利  沈柏均  阎文瑛  旭日  宋道刚
作者单位:山东脐血库,济南 250002
摘    要:
对山东脐血库保存的 4 0 0 0人份脐血的部分结果进行了统计分析 ,每份脐血的平均有核细胞数超过 1.2× 10 9,每份脐血CD34+ 细胞总量平均为 3.9× 10 6,有 76 8人份脐血有核细胞数超过 1.5× 10 9,一般可满足体重 4 0kg以上的患者使用。对基因频率的分析表明 ,常见基因与中国其他地区的统计结果相近 ,有 4 0 %的患者可以在山东脐血库找到 1个位点不合的脐血

关 键 词:山东脐血库 脐血 人类白细胞抗原 基因频率 CD34^+细胞 脐血移植 脐血保存
修稿时间:2001-06-06

Statistical Analysis of 4 000 Umbilical Cord Blood Units Preserved in Shandong Cord Blood Bank
PAN Jie,ZHOU Shen Li,SHEN Bai Jun,YAN Wen Ying,XU Ri,SONG Dao Gang. Statistical Analysis of 4 000 Umbilical Cord Blood Units Preserved in Shandong Cord Blood Bank[J]. Journal of experimental hematology, 2002, 10(3): 257-260
Authors:PAN Jie  ZHOU Shen Li  SHEN Bai Jun  YAN Wen Ying  XU Ri  SONG Dao Gang
Affiliation:Shandong Cord Blood Bank, Jinan 250002, China. Panjie@sinocord.com
Abstract:
The current study analyzed the data of 4 000 umbilical cord blood (UCB) units collected in Shandong Cord Blood Bank from the end of 1999 to March 2001. The averages of nucleated cells and CD34(+) cells were more than 1.2 x 10(9) and 3.9 x 10(6) per UCB unit respectively, and more than 1.5 x 10(9) nucleated cells per UCB unit were obtained in 768 UCB units. These UCB units are suitable for transplantation in patients with a body weight greater than 40 kg. The analysis of HLA gene frequency showed that A2, A24, A11, B13, B51, DR15, DR7 and DR9 are the common halotypes in Shandong population and similar to those in the other areas of China. 40% patients could search out at least 1 UCB unit with 1 mismatched HLA locus in Shandong Cord Blood Bank.
Keywords:umbilical cord blood  human leukocyte antigen  gene frequency  CD34 + cell
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