| 肾舒胶囊对家兔系膜增殖性肾炎ET-1和CGRP的影响 |
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| 引用本文： | 孙世珺,菅宏蕴,黄淑芬,王明杰. 肾舒胶囊对家兔系膜增殖性肾炎ET-1和CGRP的影响[J]. 中国医疗前沿, 2008, 3(13) |
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| 作者姓名： | 孙世珺 菅宏蕴 黄淑芬 王明杰 |
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| 作者单位： | 中山大学附属中山医院病理科,广东,中山,528403 |
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| 摘 要： | 目的通过观察家兔系膜增殖型肾炎(MSPGN)血内皮素(ET-1)和降钙素基因相关肽(CGRP)水平的变化,探讨肾舒胶囊治疗MSPGN的作用机制。方法应用生物化学、放射免疫和自动图像分析的方法。检测24小时尿蛋白的排泄量,血浆ET-1及CGRP及肾组织系膜基质面积的变化。结果MSPGN家兔24小时尿蛋白排泄量升高,ET-1升高,CGRP降低,系膜基质面积增大与肾舒胶囊治疗组相比具有显著性差异(P<0.05)。结论MSPGN家兔ET-1升高CGRP降低,系膜基质面积增宽。肾舒胶囊通过升高CGRP降低ET-1,降低肾小球系膜基质面积对MSPGN有明显保护作用。
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| 关 键 词： | 肾舒胶囊 内皮素 降钙素基因相关肽 系膜基质 |
Effects of ShenShu capsule on endothelin and calcitonin gene-related peptide in experimental rabbits with mesangial proliferative glomerulonephritis |
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| Sun ShiJun,Jian Hongyun,Huang SuFen,wang mingjie. Effects of ShenShu capsule on endothelin and calcitonin gene-related peptide in experimental rabbits with mesangial proliferative glomerulonephritis[J]. China Healthcare Innovation, 2008, 3(13) |
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| Authors: | Sun ShiJun Jian Hongyun Huang SuFen wang mingjie |
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| Affiliation: | Sun ShiJun Jian Hongyun Huang SuFen wang mingjie; |
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| Abstract: | Objective To investigate the effects of ShenShu capsule on the levels of plasma endothelin (ET-1)and calcitonin gene-related peptide (CGRP) in experimental rabbits with mesangial proliferative glomerulonephritis (MSPGN). It s mechanism was also explored. Methods Rabbit Mesangial proliferferative glomerulonephritis models were estaslished. 24 hours excretion quantity of urine protein (EQUP) and renal function were examined with biochemical analyses. The levels of plasma ET-1 and CGRP were tested with radioi... |
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| Keywords: | Mesangial proliferative Glomerulonephritis ShenShu capsule endothelin calcitonin gene-related peptide mesangial matrix |
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