哌罗匹隆与阿立哌唑治疗精神分裂症的对照研究

目的:比较哌罗匹隆与阿立哌唑治疗精神分裂症的疗效和安全性.方法:选择符合CCMD-3 诊断的精神分裂症患者80例,随机分为两组,分别使用哌罗匹隆与阿立哌唑口服治疗,观察8 周.以阳性与阴性症状量表(PANSS)减分率评定疗效,用治疗中出现的症状量表(TESS)评定不良反应.结果:治疗结束时,哌罗匹隆组与阿立哌唑组在有效率、PANSS评分和不良反应两组比较差异无统计学意义(P>0.05).结论:哌罗匹隆与阿立哌唑治疗精神分裂症疗效均好,不良反应轻.

A clinical control study of Perospirone and Aripiprazole in schizophrenia

Objective:To compare the efficacy and safety of Perospirone and Aripiprazole in the treatment of Schizophrenia.Methods:80 patients with schizophrenia by CC MD-3 were randomly into two groups treated with Perospirone or Aripiprazole for 8 weeks.The ratio of the reduction of Positive and Negative Symptom Scale(PANSS) was used to assess efficacy,and the treatment emergent symptom scale(TESS) was used to assess side effects.Results: In the end of curing,the two groups showed no statistical difference in the efficacy rate,the scores of PANSS,and the adverse effect(P>0.05).Conclusions: Both Perospirone and Aripiprazole are effective and few adverse effect for patients with schizophrenia.