| 大鼠脑缺血再灌注后血脑屏障通透性的改变 |
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| 引用本文： | 王社军,杜长生,唐红,李钟铭,冯兴军,张欣健,李永哲. 大鼠脑缺血再灌注后血脑屏障通透性的改变[J]. 武警医学, 2005, 16(10): 745-747 |
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| 作者姓名： | 王社军 杜长生 唐红 李钟铭 冯兴军 张欣健 李永哲 |
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| 作者单位： | 首都医科大学博士后流动站、武警总医院博士后工作站,北京,100069;武警总医院神经外科,北京,100039;哈尔滨医科大学附属第二医院神经外科,哈尔滨,150086 |
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| 摘 要： | 目的探讨大鼠脑缺血再灌注后血脑屏障(BBB)通透性的改变.方法采用线栓法制备大鼠局灶性脑缺血再灌注模型,通过测定脑组织中伊文蓝(EB)含量及免疫组化法来观察血脑屏障通透性的改变.结果缺血2 h再灌注3 h,BBB通透性开始增加,24 h达高峰,72 h后明显减弱.结论缺血再灌注后BBB的通透性在24 h内逐渐增加,提示脑梗死超早期给予溶栓是可行的.
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| 关 键 词： | 缺血再灌注 血脑屏障 通透性 |
| 收稿时间： | 2004-12-10 |
| 修稿时间： | 2004-12-10 |
Permeability of blood- brain barrier during reperfusion after middle cerebral artery occlusion |
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| WANG Shejum,DU Changsheng,TANG Hong,LI Zhongming,FENG Xingjum,ZHANG Xinjian,LI Yongzhe. Permeability of blood- brain barrier during reperfusion after middle cerebral artery occlusion[J]. Medical Journal of the Chinese People's Armed Police Forces, 2005, 16(10): 745-747 |
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| Authors: | WANG Shejum DU Changsheng TANG Hong LI Zhongming FENG Xingjum ZHANG Xinjian LI Yongzhe |
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| Abstract: | Objective To study the changes in permeability of blood-brain barrier(BBB) at different time points of reperfusion after middle cerebral artery occlusion(MCAO).Methods We observed the changes in permeability of BBB by measuring the amount of EB in brain and using immunohistochemical technology.Results At 3 h of reperfusion after cerebral ischemia for 2 h,the permeability of BBB began to increase,reached the peak at 24 h of reperfusion and was still elevated at 72 h,and afterwards began to decrease.Conclusion The permeability of BBB after reperfusion subsequent to cerebral ischemia is gradually increased in 24 h,suggesting that thrombolysis at ultraearly period of cerebral infarction is feasible. |
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| Keywords: | Reperfusion after cerebral ischemia Blood-brain barrier Permeability |
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