Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis |
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Authors: | S Brummelte J Neddens G Teuchert-Noodt |
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Institution: | (1) Department of Neuroanatomy, Faculty of Biology, University of Bielefeld, Bielefeld, Germany |
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Abstract: | Summary. The GABAergic input on cortical pyramidal cells has an important influence on the firing activity of the cortex and thus in
regulating the behavioural outcome. The aim of the current study was to investigate the long-term neuroplastic adaptation
of the GABAergic innervation pattern after an early severe systemic impact. Therefore 40 Mongolian gerbils (Meriones unguiculatus) were either reared under impoverished (IR) or enriched rearing conditions (ER) and received a single early (+)-methamphetamine
(MA) challenge (50 mg/kg i.p.) or saline on postnatal day 14. The density of perisomatic immunoreactive GABAergic terminals
surrounding layers III and V pyramidal neurons was quantified as well as the overall GABAergic fibre density in layers I/II
and V of the medial prefrontal cortex (mPFC) of young adult animals (90 days). We found that IR in combination with an early
MA administration led to a significant decrease in GABAergic bouton densities while the overall GABAergic fibre density increased
in all investigated layers. The results indicate a shift in inhibition from somatic to dendritic innervation of pyramidal
neurons in this potential animal model of psychosis. We conclude that IR combined with early MA trigger changes in the postnatal
maturation of the prefrontal cortical GABAergic triggers innervation, which may interfere with proper signal processing within
the prefrontal neural network. |
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Keywords: | : GABA immunohistochemistry schizophrenia gerbil |
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