肝动脉栓塞化疗患者甘草甜素的保肝作用

目的：观察甘草甜素(SNMC)在肝动脉栓塞化疗时保肝作用．方法：20例原发性肝癌在动脉栓塞化疗当天给予美能保肝，并设18例为对照．结果：治疗组治疗前后肝功能变化无统计学意义，对照组胆红素(BIL)3d升高，2wk末降至正常，丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)在3d和7d时明显升高，2wk末降至正常，白蛋白(A1b)7d开始下降，2wk回升，但仍未升至正常水平．结论：美能可防止正常肝细胞损害，保护肝功能，增强对栓塞化疗时的耐受性。

Protective effects of stronger neo-minophagen C on liver in patients treated by trans-catheter arterial chemoembolization

AIM: To observe the protective effects of stronger neo-minophagen C (SNMC) on liver function during trans-catheter arterial chemoembolization (TCAC). METHODS: SNMC was given to 20 patients the day when they received TCAC and 18 patients were taken as control. RESULTS: The liver function remained unchanged before and after TCAC in treatment group. But in the control group, the BIL elevated 3 d after TCAC and restored to normal 2 weeks later; ALT and AST increased 3 d and 7 d after TCAC and restored to normal 2 weeks later. Alb decreased 7 d after TCAC and increased 2 weeks after, but did not restore to the normal level. CONCLUSION: SNMC can protect hepatocytes from damage and improve the tolerance of liver to TCAC.