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| rIL—2激活的人胃癌引流区淋巴结淋巴细胞的体内外抗肿瘤抗转移活性 | |
| 引用本文： | 孟晓波,史历,徐震逸,巴德年. rIL—2激活的人胃癌引流区淋巴结淋巴细胞的体内外抗肿瘤抗转移活性[J]. 中国免疫学杂志, 1989, 0(3) |
| 作者姓名： | 孟晓波 史历 徐震逸 巴德年 |
| 作者单位： | 哈尔滨医科大学肿瘤研究所免疫室，哈尔滨医科大学肿瘤研究所免疫室，哈尔滨医科大学肿瘤研究所免疫室，哈尔滨医科大学肿瘤研究所免疫室 哈尔滨 150040，哈尔滨 150040，哈尔滨 150040，哈尔滨 150040 |
| 摘 要： | 外科手术中切除的人胃癌引流区淋巴结经细胞分离器分离之后.能获得大量的淋巴细胞(TdLNL)。将TdLNL与基因重组IL—2(rIL—2)共同培养5天后,TdLNL对同种AniP—973肿瘤细胞产生了明显的体外杀伤。同时,rIL—2激活的TdLNL还能抑制An(?)p—933在BALB/c nu/nu裸小鼠皮下的生长和自发性肺转移。 |
| 关 键 词： | 基因重组白细胞介素2 肿瘤转移 胃癌引流区淋巴结淋巴细胞 |
LAK activity of IL-2 activiated human gastric/carcinoma drained lymph node lymphocytes |
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| Meng Xiaobo,et al.. LAK activity of IL-2 activiated human gastric/carcinoma drained lymph node lymphocytes[J]. Chinese Journal of Immunology, 1989, 0(3) | |
| Authors: | Meng Xiaobo et al. |
| Affiliation: | Meng Xiaobo,et al. Cancer Institute,Harbin Medical University,Harbin,China. |
| Abstract: | In the present study we obtained a large guantity of lymphocytes from human gastric carcinoma drained lymph nodes (TdLNL). After culturing with1000u/ml rIL-2 for 5 days, TdLNL became cytotoxic to allogenic humanlung adenocarcinoma cell strain (Ani p-973)in vitro. In a Winn-type assay BALB/c nu/nu mice were inoculated subcutaneousl y with Anip-973 and TdLNL at 10/1 E/T ratio. The results showed that the rIL-2 activiated TdLNL could not only inh(?)t the growth of Anip-973, but also prevent the formation of spontaneous pulmonary metastases, which suggest that TdLNL might be used as a new LAK source in adoptive immunotherapy for cancer patients. |
| Keywords: | Recombinant Interleukin 2 Lymphokine-Activiated Killer Tumor Drained Lymph Nodes Lymphocytes. |
| 本文献已被 CNKI 等数据库收录！ | |