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新型芳香呋喃香豆素衍生物的合成
引用本文:沈琼,张万金,罗艳,古练权. 新型芳香呋喃香豆素衍生物的合成[J]. 广东药学院学报, 2005, 21(6): 647-648,657
作者姓名:沈琼  张万金  罗艳  古练权
作者单位:广东药学院,药物化学教研室,广东,广州,510006;中山大学,药学院,广东,广州,510275
基金项目:国家自然科学基金重点资助项目(20032020)
摘    要:目的合成新型芳香呋喃香豆素衍生物。方法以间苯二酚为原料,通过贝克曼反应,威廉逊反应.关环、芳构化反应得到目标物。结果合成得到两个目标化合物,其结构经。HNMR、IR、FAB.MS确证。结论目标化合物有望成为新的光化疗药物。

关 键 词:芳香苯并呋喃香豆素衍生物  设计  合成
文章编号:1006-8783(2005)06-0647-02
收稿时间:2005-10-20
修稿时间:2005-10-202005-12-05

Synthesis and characterization of benzofurocoumarins
SHEN Qiong,ZHANG Wan-jin,LUO Yan,GU Lian-Quan. Synthesis and characterization of benzofurocoumarins[J]. Academic Journal of Guangdong College of Pharmacy, 2005, 21(6): 647-648,657
Authors:SHEN Qiong  ZHANG Wan-jin  LUO Yan  GU Lian-Quan
Affiliation:1. School of Pharmaceutical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China; 2. Sun Yat-sen University, Guangzhou 510275, China
Abstract:Objective To synthesis benzofurocoumarin derivatives with potential use in cancer photochemotherapy. Methods Resorcinol and 2 -cyclohexanonecarboxylate were used as starting materials. Upon Pechmann reaction, Williamson reaction, cyclization and aromatization, benzofurocoumarin derivatives were synthesized. Result and Conclusion Two compounds of benzofurocoumarins were synthesized and their structures were characterized by ^1HNMR, IR and FAB - MS.
Keywords:benzofurocoumarins    synthesis    characterization
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