Regulatory T cells and inflammatory bowel disease. |
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Authors: | H Groux F Powrie |
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Affiliation: | 1. Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Faculty of Medicine and Surgery, Second University of Naples, Via Santa Maria di Costantinopoli, 16, 80138 Naples, Italy;2. Department of Biochemistry, Biophysics and General Pathology, Faculty of Medicine and Surgery, Second University of Naples, Via Santa Maria di Costantinopoli, 16, 80138 Naples, Italy;3. Department of Clinical Pathology, A. Cardarelli Hospital, Via Antonio Cardarelli, 9, 80133 Naples, Italy;1. Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt;2. Department of Histology and Cell Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt;3. Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt |
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Abstract: | Recent studies have identified interleukin 10 as a differentiation factor for a novel subset of immune suppressive regulatory T cells. Here, Hervé Groux and Fiona Powrie discuss the role that these cells play in the regulation of immune responses to enteric antigens and suggest that a deficiency in these cells might be involved in the pathogenesis of inflammatory bowel disease. |
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