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Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease With Early Motor Complications
Authors:Michael T. Barbe MD  Lisa Tonder MS  Paul Krack MD  PhD  Bettina Debû MD  Michael Schüpbach MD  Steffen Paschen MD  Till A. Dembek MD  Andrea A. Kühn MD  Valerie Fraix MD  Christine Brefel-Courbon MD  PhD  Lars Wojtecki MD  PhD  David Maltête MD  PhD  Phillippe Damier MD  PhD  Friederike Sixel-Döring MD  Daniel Weiss MD  Marcus Pinsker MD  PhD  Tatiana Witjas MD  PhD  Stephane Thobois MD  PhD  Carmen Schade-Brittinger B.Sc  Jörn Rau MSc  Jean-Luc Houeto MD  PhD  Andreas Hartmann MD  PhD  Lars Timmermann MD  PhD  Alfons Schnitzler MD  PhD  Valerie Stoker MPH  Marie Vidailhet MD  PhD  Günther Deuschl MD  PhD  for the EARLYSTIM study group
Affiliation:1. Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;2. Medtronic, Minneapolis, Minnesota, USA;3. Department of Neurology, University Hospital Bern and University of Bern, Bern, Switzerland;4. Université Grenoble Alpes, INSERM 1216, Grenoble Institut Neurosciences, Grenoble, France;5. Neurology Department, Grenoble University Hospital, Grenoble, France;6. Department of Neurology, University Hospital Bern and University of Bern, Bern, Switzerland

Assistance-Publique Hôpitaux de Paris;7. Centre d'Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière;8. Département de Neurologie, Université Pierre et Marie Curie-Paris 6 et INSERM, CHU Pitié-Salpêtrière, Paris, France

Institute of Neurology, Konolfingen, Switzerland;9. Department of Neurology, UKSH, Kiel Campus Christian-Albrechts-University, Kiel, Germany;10. Department of Neurology, Charité–Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany;11. Neurology Department, Grenoble University Hospital, Grenoble, France

Neurology Department, Grenoble University Hospital, Grenoble, France;12. Department of Neurology, INSERM Unite 1214, University Hospital Toulouse, France;13. Institute of Clinical Neuroscience and Medical Psychology, and Department of Neurology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany;14. Department of Neurology, Rouen University Hospital and University of Rouen, Rouen, France;15. INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Mont-Saint-Aignan, France;16. CHU Nantes, INSERM, CIC1413, Hôpital Laënnec, Nantes, France;17. Paracelsus-Elena-Klinik Kassel, Kassel, Germany;18. Centre of Neurology, Department for Neurodegenerative Diseases, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany;19. Division of Stereotactic and Functional Neurosurgery, University Medical Center, Freiburg, Freiburg, Germany;20. Department of Neurology, Timone University Hospital, UMR 7289, CNRS Marseille, Marseille, France;21. Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson, Bron, France;22. Université Lyon, Université Claude Bernard Lyon 1, Faculté de Médecine Lyon Sud Charles Mérieux, Oullins, France;23. The Coordinating Center for Clinical Trials, Philipps University, Marburg, Germany;24. Department of Neurology, CIC-INSERM 1402, CHU of Poitiers, University of Poitiers, Poitiers, France;25. Assistance-Publique Hôpitaux de Paris;26. Département de Neurologie, Université Pierre et Marie Curie-Paris 6 et INSERM, CHU Pitié-Salpêtrière, Paris, France;27. Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

Universitätsklinikum Giessen und Marburg, Marburg Campus, Marburg, Germany;28. Sorbonne Université, ICM UMR1127, INSERM &1127, CNRS 7225, Department of Neurology, Salpêtriere University Hospital, AP-HP, Paris, France

Abstract:
Keywords:axial signs  deep brain stimulation  EARLYSTIM  freezing of gait
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