| 紫杉醇的聚乙二醇单甲醚-b-聚(L-乳酸)二嵌段共聚物纳米粒的研究 |
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| 引用本文： | 邓联东,孙多先,张跃庭,霍建中,元英进,董岸杰. 紫杉醇的聚乙二醇单甲醚-b-聚(L-乳酸)二嵌段共聚物纳米粒的研究[J]. 生物医学工程学杂志, 2005, 22(4): 715-718 |
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| 作者姓名： | 邓联东 孙多先 张跃庭 霍建中 元英进 董岸杰 |
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| 作者单位： | 1. 天津大学,化工学院,天津,300072
2. 天津师范大学,化学与生命科学学院,天津,300074 |
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| 基金项目： | 国家自然科学基金资助课题(30170227) |
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| 摘 要： | 采用自乳化溶剂蒸发法制备负载紫杉醇的聚乙二醇单甲醚-b-聚(L-乳酸)二嵌段共聚物纳米粒(Paclitaxel-loadedmethoxypoly(ethyleneglycol)-b-poly(L-lacticacid)diblockcopolymernanoparticles,PMT),采用动态光散射、紫外分光光度计、透射电子显微镜和高压液相色谱等手段研究了PMT的形态结构、粒径和粒径分布、体外释放等。实验结果表明PMT呈核/壳结构的球形,粒径为纳米级,随着载药量的增大而增大;PMT的体外释放无突释现象,释放速率缓慢,且随着释放液置换量的增大,累积释放量增大。本研究为开发紫杉醇新型静脉注射制剂提供了实验依据。
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| 关 键 词： | 紫杉醇 聚乙二醇单甲醚-b-聚(L-乳酸) 嵌段共聚物 体外释放 |
| 收稿时间： | 2003-06-06 |
| 修稿时间： | 2003-06-062003-09-28 |
Studies on Paclitaxel-loaded Methoxy Poly(ethylene glycol)/Poly(L-lactic acid) Diblock Copolymer Nanoparticles |
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| Deng Liandong,Sun Duoxian,Zhang Yueting,HUO Jianzhong,Yuan Yingjin,Dong Anjie. Studies on Paclitaxel-loaded Methoxy Poly(ethylene glycol)/Poly(L-lactic acid) Diblock Copolymer Nanoparticles[J]. Journal of biomedical engineering, 2005, 22(4): 715-718 |
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| Authors: | Deng Liandong Sun Duoxian Zhang Yueting HUO Jianzhong Yuan Yingjin Dong Anjie |
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| Affiliation: | 1 School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072,China; 2 Chemistry and Life Science College, Tianjin Normal University, Tianjin 300074,China |
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| Abstract: | Paclitaxel-loaded methoxy poly(ethylene glycol)-b-poly(L-lactic acid)diblock copolymer nanoparticles (PMT) were prepared by a self-emulsification/solvent evaporation method. The PMT morphology, size and its distribution, and drug release in vitro were investigated by DLS, UV, TEM and HPLC. The results indicate that PMT show a spherical morphology with inner core and outer shell. The diameter(nm) of PMT increases with the increase of the drug-loaded amount. The initial burst release is not observed, the drug releasing rate in vitro is lower, and the accumulated release increases with the increase of replacement amout of the pH7.4 medium. This study develops a new formulation for paclitaxel and provides an experimental basis for the intravenous administration of paclitaxel. |
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| Keywords: | Paclitaxel Methoxy poly(ethylene glycol)-b-poly(L-lactic acid) Block copolymer Release in vitro |
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