PSA、PSAD和PSAT对前列腺癌诊断的比较

目的　比较前列腺移行带特异性抗原密度（PSAT）与前列腺特异性抗原（PSA）及前列腺特异性抗原密度（PSAD）在前列腺癌诊断中的意义。方法　对78例PSA4～20ng/ml的患者行前列腺穿刺活检后比较PSA、PSAD和PSAT指标。结果　78例中，病理诊断为前列腺癌(PCa)32例，良性前列腺增生(BPH)46例，二者PSA平均值分别为(14.32±1.46)ng/ml、(13.89±1.52)ng/ml，二者相比差别无显著性意义(P>0.05)；PSAD平均值分别为0.43±0.14、0.36±0.17，二者相比差别有显著性意义(P<0.05)；PSAT平均值分别为0.75±0.19、0.31±0.06，二者相比差别有非常显著性意义(P<0.01)。结论　PSAD和PSAT对预测PSA<20ng/ml的患者是否患前列腺癌有较大帮助，特别是PSAT更为准确。

A comparative study of PSA,PSAD and PSAT in the diagnosis of prostate cancer

Objective　To study and to compare the prostate specific antigen density of the transitional zone(PSAT),the prostate specific antigen (PSA) and prostate specific antigen densigy (PSAD) in the diagnosis of prostate carcinoma.Methods　From Aug. 1998 to Nov.1999,78 cases with a serum PSA 4～20 ng/ml underwent biopsy of the prostate.After the histopathological diagnosis has been established,the value of PSA,PSAD and PSAT were evaluated.Results　Of the 78 cases,32 were prostate cancer (Pca) and 46 benign prostatic hyperplasia (BPH).The mean value of PSA in Pca and BPH patients were (14.32±1.46) ng/ml and (13.89±1.52) ng/ml,the difference being statistically insignificant.The mean value of PSAD were 0.43±0.14 and 0.36±0.17,the difference was statistically significant (P<0.05).The mean value of PSAT were 0.75±0.19 and 0.31±0.06,the difference of PSAT was statistically very significant (P<0.01).Conclusions　PSAD and PSAT are valuable and helpful in the screening diagnosis of prostate cancer in patients with PSA less than 20 ng/ml.PSAT seems to be more reliable.