In vitro activity of SCH 27899 (Ziracin) against Legionella species |
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| Affiliation: | 1. Department of Pathology and Laboratory Medicine (PHE, MACE), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA;2. Department of Medicine (PHE), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA;1. Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, MD, USA;2. Department of Environmental Health, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA;3. Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, College Park, MD, USA;2. Travel Vaccination Clinic, Queensland Health Pathology Service, Royal Brisbane Women’s Hospital, Herston, Queensland, Australia;3. Griffith University, Royal Brisbane Hospitals Campus, Herston, Queensland, Australia;4. Respiratory Medicine, Royal Childrens Hospital, Herston, Queensland, Australia;2. Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Via Celoria 10, 20133, Milan, Italy;3. M-team and Mastitis and Milk Quality Research Unit, Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium;4. Flanders Milk Control Center, Hagenbroeksesteenweg 167, 2500 Lier, Belgium;6. Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Via Bianchi 9, 25124 Brescia, Italy;5. Dipartimento di Medicina Animale, Produzioni e Salute (MAPS), Università degli Studi di Padova, Viale dell''Università 16, 35020 Legnaro, (PD), Italy;1. Faculty of Engineering Technology, Universiti Malaysia Pahang (UMP), Lebuhraya Tun Razak, 26300 Gambang, Kuantan, Pahang, Malaysia;2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, NIPER-Ahmedabad, India;3. Department of Biosciences, HPU, Summer Hill, Shimla 171005, India |
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| Abstract: | ![]()
The activities of Sch 27899 (Ziracin), erythromycin, and ofloxacin against 102 Legionella spp. isolates were measured by a microbroth dilution method. The MICs that inhibited 90% of strains tested were 0.25, 0.5, and 0.06 μg/mL for Sch 27899, erythromycin, and ofloxacin, respectively. The activity of Sch 27899 against intracellular Legionella pneumophila could not be determined because of complete inactivation of the drug by tissue culture medium components. |
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