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| 前列腺素E_2对人T淋巴祖细胞增殖和T淋巴细胞转化的调节 | |
| 引用本文： | 王慧,吴轰,卿之驹,方建珍,李春海. 前列腺素E_2对人T淋巴祖细胞增殖和T淋巴细胞转化的调节[J]. 中南大学学报(医学版), 1989, 0(2) |
| 作者姓名： | 王慧 吴轰 卿之驹 方建珍 李春海 |
| 作者单位： | 湖南医科大学第二附属医院中心实验室(王慧，吴轰，卿之驹，方建珍)，中国军事医学科学院基础医学研究所(李春海) |
| 摘 要： | 用半固体的液体培养,观察前列腺素E_2对人外周血T淋巴祖细胞增殖和T淋巴细胞转化的调节。在体外,前列腺素E_2对二者均有明显的抑制作用。加入消炎痛阻滞前列腺素E_2的合成,可使淋巴祖细胞集落增加。 |
| 关 键 词： | 前列腺素E_2 T淋巴细胞 集落形成单位测定 淋巴细胞转化 消炎痛 药物作用 |
PROSTAGLANDIN E_2 MODULATION OF HUMAN TL-CFU AND LYMPHOCYTE TRANSFORMATION |
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| Wang Hui Wu Hong Qing Zhiju Fan JianzhenCantral Lab.,The Second Affiliated Hospital,Hunan Medical UniversityLi ChunhaiInstitute of Basic Medicine,Academy oj Military Medical Sciences. PROSTAGLANDIN E_2 MODULATION OF HUMAN TL-CFU AND LYMPHOCYTE TRANSFORMATION[J]. Journal of Central South University. Medical sciences, 1989, 0(2) | |
| Authors: | Wang Hui Wu Hong Qing Zhiju Fan JianzhenCantral Lab. The Second Affiliated Hospital Hunan Medical UniversityLi ChunhaiInstitute of Basic Medicine Academy oj Military Medical Sciences |
| Abstract: | Prostaglandin E2 ( PGE2) modulation of human T cell colony forming unit and lymphocyte transformation in vitro is reported. PGE2inhibited TL-CFU and lymphocyte transformation markedly with a dose-effect relation. It ranged 15.4-68.2% and 25.1-54.6% at concentrations between 10-11-10-9M. PEG2biosynthesis blocked by indomethacin resulted a 24.6 + 7.2% increase in TL-CFU. The E-rosettes forming test (E-rosette positive 79%) OKT monoclonal antibody assay (OKT3+ 79%, OKT8+ 48%, OKT4+ 52%) showed that these colonies comprised mature functional T cells. |
| Keywords: | prostaglandin E_2 T lymphocytes colonic forming unit assay lymphocyte transformation indomethacin |
| 本文献已被 CNKI 等数据库收录！ | |