鼻咽癌单程与再程放射治疗后放射性脑损伤临床分析

目的探讨鼻咽癌单程与再程放疗后放射性脑损伤(REP)的临床特点。方法回顾性分析2 103例鼻咽癌放疗患者的临床资料,总结单程放疗后REP和再程放疗后REP患者的临床特点。结果鼻咽癌再程放疗患者REP发生率(9.60%)明显高于单程放疗者(2.07%,P<0.05);再程放疗后REP组REP中位潜伏期(2 a)明显短于单程放疗后REP组(5 a,P<0.05);再程放疗后REP组REP患者死亡率(33.3%)明显高于单程放疗后REP组(7.32%,P<0.05)。结论鼻咽癌放疗后REP发生部位与放疗程数无明显相关性,但放疗后REP发病率、中位潜伏期、及患者死亡率与放疗程数有明显相关性。

Clinical study of radiation encephalopathy after single-pass radiotherapy and re-course radiotherapy in nasopharyngeal carcinoma

Objective To discuss the clinical features of radiation encephalopathy（REP） after single-pass radiotherapy and re-course radiotherapy in nasopharyngeal carcinoma（NPC）.Methods The clinical data of 2 103 patients with NPC were retrospectivly analyzed,and the clinical features of REP after single-pass radiotherapy and re-course radiotherapy were summarized.Results The incidence of REP in re-course radiotherapy group（9.60%） was higher than that in single-pass radiotherapy group（2.07%,P〈0.05）.The median latency period of REP was shorter in re-course radiotherapy group（2 a） than that in single-pass radiotherapy group（5 a,P〈0.05）.The case fatality rate was higher in re-course radiotherapy group（33.3%） than that in single-pass radiotherapy group（7.32%,P〈0.05）.Conclusion The location of REP after radiotherapy in nasopharyngeal carcinoma has no significant correlation with single-pass and re-course radiotherapy,but the incidence,the median latency period,and the mortality of REP have significant correlations with single-pass and re-course radiotherapy.