| 蛋白质芯片在鼠疫患者血清抗体谱检测中的应用 |
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| 引用本文： | 于守鸿,李蓓,李敏,王丽,谢辉,祁美英,杨瑞馥. 蛋白质芯片在鼠疫患者血清抗体谱检测中的应用[J]. 中国地方病学杂志, 2006, 25(5): 571-572 |
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| 作者姓名： | 于守鸿 李蓓 李敏 王丽 谢辉 祁美英 杨瑞馥 |
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| 作者单位： | 1. 811602,西宁,青海省地方病预防控制所
2. 军事医学科学院微生物流行病研究所分析微生物实验室 |
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| 摘 要： | 目的检测鼠疫患者血清抗体谱,为鼠疫的疫苗研究奠定基础。方法利用鼠疫耶尔森氏菌毒流力相关蛋白的蛋白质芯片检测鼠疫患者血清抗体谱。结果利用一个包含145个鼠疫菌毒力相关蛋白的蛋白质芯片,在鼠疫患者血清中检测到37种鼠疫菌蛋白相应的抗体。结论通过对鼠疫患者血清抗体谱的分析,寻找到新的能在人体内产生体液免疫的蛋白。
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| 关 键 词： | 耶尔森菌，鼠疫 蛋白质芯片 抗体 |
| 收稿时间： | 2005-08-22 |
| 修稿时间： | 2005-08-22 |
The application of protein microarray for the antibody profiling in plague patients |
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| YU Shou-hong,LI Bei,LI Min,Wang Li,XIE Hui,QI Mei-ying,YANG Rui-fu. The application of protein microarray for the antibody profiling in plague patients[J]. Chinese Jouranl of Endemiology, 2006, 25(5): 571-572 |
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| Authors: | YU Shou-hong LI Bei LI Min Wang Li XIE Hui QI Mei-ying YANG Rui-fu |
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| Affiliation: | Qinghai Province Institute for Endemic Disease Prevention and Control, Xining 811602, China |
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| Abstract: | Objective To detect antibody profile in plague patients to lay a foundation for diagnostic anti vaccine development.Methods A protein microarray containing 145 Yersinia pestis virulence-related proteins was used to profile the humoral responses against Yersinia pestis in plague patient.Results Antibodies up to 37 proteins of Yersinia pestis were detected in the plague patient.Conclusions Through the analysis of antibody profiles of plague patients,novel proteins which can induce the humoral immune response in human have been found. |
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| Keywords: | Yersinia pestis Protein microarray Antibodies |
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