Factors affecting QuickVue Influenza A + B rapid test performance in the community setting |
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| Authors: | Calvin KY Cheng Benjamin J Cowling Kwok Hung Chan Vicky J Fang Wing Hong Seto Raymond Yung Timothy M Uyeki Peter M Houck JS Malik Peiris Gabriel M Leung |
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| Institution: | 1. Department of Community Medicine and School of Public Health, The University of Hong Kong, Hong Kong;2. Department of Microbiology, The University of Hong Kong, Hong Kong;3. Department of Microbiology, Queen Mary Hospital, Hospital Authority, Hong Kong;4. Centre for Health Protection, Department of Health, Government of the Hong Kong SAR, Hong Kong;5. Influenza Division, Centers for Disease Control and Prevention (CDC), National Center for Preparedness, Detection, and Control of Infectious Diseases (NCPDCID), Atlanta, Georgia 30333, USA;6. Seattle Quarantine Station, Division of Global Migration and Quarantine, NCPDCID, CDC, Seattle, Washington 98158, USA |
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| Abstract: | Rapid diagnosis of influenza can facilitate timely clinical management. We evaluated the performance of the QuickVue Influenza A + B test (Quidel, San Diego, CA) in a community setting and investigated the factors affecting test sensitivity. We recruited 1008 subjects from 30 outpatient clinics in Hong Kong between February and September 2007. Each subject provided 2 pooled pairs of nose and throat swabs; 1 pair was tested by the QuickVue rapid test on site, and the other pair was sent to a laboratory for reference tests. Among 998 enrolled subjects with valid results, the rapid test had overall sensitivity of 0.68 and specificity of 0.96 compared with viral culture. Sensitivity for both influenza A and B was significantly higher for specimens with viral loads greater than 5 log10 copies/mL. The QuickVue Influenza A + B test has similar sensitivity in point-of-care community settings to more controlled conditions. |
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| Keywords: | Human influenza Immunoassay Diagnostic tests Sensitivity Specificity Viral load |
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