二氧化碳点阵激光治疗萎缩性痤疮瘢痕的临床疗效和安全性研究

目的:评估二氧化碳点阵激光治疗萎缩性痤疮瘢痕的临床疗效和安全性。方法:本研究选择2014年6月-2018年6月在笔者科室接受治疗的140例萎缩性痤疮瘢痕患者。所有患者均接受3次二氧化碳点阵激光治疗,每次治疗间隔3个月。每次治疗后的1周以及末次治疗的1、3、6个月后进行随访观察。由3名独立的皮肤科医生根据第一次治疗前和最后一次治疗后6个月的照片评估患者的改善程度,并且记录治疗不良反应。最后一次随访时,患者对满意度进行自我评估。结果:136例患者均完成了整个治疗。经3次治疗后,患者的萎缩性痤疮瘢痕显著改善。痤疮瘢痕权重评分(ECCA)从107.21减少到42.27(P<0.05);所有患者的斑点、毛孔粗大、细纹、紫外线伤害以及红斑均显著改善,均对治疗效果自我评价为“非常满意”或“满意”。结论:二氧化碳点阵激光治疗萎缩性痤疮瘢痕安全、有效,值得在临床上推广应用。

Prospective Study of Clinical Effi cacy and Safety of CO2 Dot Laser Technique in the Treatment of Atrophic Acne Scars

Objective This study was designed to evaluate the clinical efficacy and safety of CO2 laser technology in the treatment of atrophic acne scars.Methods This study included 140 patients with atrophic acne scars who were treated in our dermatology clinic from June 2014 to June 2018.All patients received 3 cycles of CO2 laser technology,with each treatment interval of 3 months.Follow-up observations were performed 1 week after each treatment,and 1,3,and 6 months after the last treatment.The degree of improvement was assessed by three independent dermatologists based on photographs before the fi rst treatment and 6 months after the last treatment,and the adverse effects of the treatment were recorded.At the last follow-up,the patient also self-assessed satisfaction.Results A total of 136 patients completed the entire study.After 3 treatments,all patients had signifi cant improvement in spots,enlarged pores,lines,UV damage,and erythema.All patients self-evaluated the treatment effect as"very satisfi ed"or"satisfi ed".Conclusion CO2 laser technology is effective and safe for atrophic acne scars,and it is worthy of clinical application.