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| 醌氧化还原酶1 C609T基因多态性与大肠癌关系 | |
| 引用本文： | 彭仙娥,江荧荧,史习舜,胡志坚,郑霄雁,肖景榕,林旭. 醌氧化还原酶1 C609T基因多态性与大肠癌关系[J]. 中国公共卫生, 2010, 26(4) |
| 作者姓名： | 彭仙娥 江荧荧 史习舜 胡志坚 郑霄雁 肖景榕 林旭 |
| 作者单位： | 1. 福建医科大学公共卫生学院流行病与卫生统计系,福州,350004 2. 福建省肿瘤医院流行病学办公室 3. 福建医科大学分子医学研究中心 |
| 基金项目： | 福建省教育厅科技基金(JA05255) |
| 摘 要： | 目的探讨NQO1基因C609T变异与大肠癌易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)基因分型技术,对268对大肠癌患者和对照者NQO1基因cDNA609位点多态性进行测定。结果病例组中基因型为C/C、C/T、T/T的分别有68,149,69例,分别占23.77%,52.10%和24.13%;对照组分别有116,126,44人,占40 56%,44.06%和15.38%;3种基因型频率在2组中分布差异均有统计学意义(P0.05);以C/C基因型作为参照基因型,C/T和T/T2种基因型的调整OR分别为2.06(95%CI=1.37~3.10)和2.64(95%CI=1.57~4.44);NQO1C609T变异基因型与吸烟、饮用水及食物类型存在交互作用而增加个体患大肠癌的危险。结论携带NQO1C609T,变异基因型个体患大肠癌的风险增加,且该变异基因型与环境因素具有协同致癌作用。 |
| 关 键 词： | 大肠癌 NQO1 基因多态性 病例对照研究 |
Relationship between NQO1 C609T gene polymorphism and risk of colorectal cancer |
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| PENG Xian-e,JIANG Ying-ying,SHI Xi-shun,et al.. Relationship between NQO1 C609T gene polymorphism and risk of colorectal cancer[J]. Chinese Journal of Public Health, 2010, 26(4) | |
| Authors: | PENG Xian-e JIANG Ying-ying SHI Xi-shun et al. |
| Affiliation: | PENG Xian-e,JIANG Ying-ying,SHI Xi-shun,et al.Public Health School,Fujian Medical University(Fuzhou 350004,China) |
| Abstract: | Objective To explore the relationship between NQO1 C609T gene polymorphism and the risk of colorectal cancer.Methods A hospital-based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was used to detect the genotypes.Results The frequency of C/T,T/T genotype among cases with colorectal cancer were higher than those among the controls.As compared with the C/C genotypes,the NQO1 C/T,T/T genotype significantly increased the risk for develop... |
| Keywords: | colorectal cancer NQO1 gene polymorphism case-control study |
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