慢性乙型肝炎病理组织纤维化程度与中医证型的研究

[目的]分析慢性乙型肝炎（以下简称为慢乙肝）患者肝组织病理特点与中医证型的分布规律,为中医证型运用于判断慢乙肝纤维化程度提供客观材料。[方法]选取2011年11月至2013年3月浙江中医药大学第一附属医院及丽水市人民医院感染科住院的310例慢乙肝患者,监测肝组织病理活检肝纤维化指标,观察上述指标与中医辨证分型的关系。[结果]310例慢乙肝以肝郁脾虚型居多,其次为湿热中阻型、肝肾阴虚型、脾肾阳虚型、瘀血阻络型。而肝郁脾虚型、湿热中阻型、肝肾阴虚型、脾肾阳虚型都以S2期纤维化为主,瘀血阻络型以纤维化S4期为主;212例轻型慢性乙型病毒性肝炎患者肝郁脾虚、湿热中阻相对平和质在纤维化≥S2间具有差异,并具有统计学意义（P〈0.05）。[结论]慢乙肝患者肝组织病理及中医证型分布具有一定规律性;中医证型与客观的肝组织病理变化具有相关性。

Research on Chronic Hepatitis B Fibrosis in Liver Tissue Pathology and TCM Syndrome Type

[Objective]Analysis of chronic hepatitis B（hereinafter referred to as b） distribution in liver tissue pathology and TCM syndrome type, provide the objective material to determine the chronic hepatitis B fibrosis degree of TCM use. [Method] From 2011 November to 2013 March in Zhejiang Chinese Medicine University First Affiliated Hospital and Lishui People＇s Hospital hospital infection 310 cases of patients with chronic hepatitis B, monitoring the liver biopsy and liver fibrosis indexes, to investigate the relationship between the above indexes and the TCM syndrome types. [Results] 310 cases of chronic hepatitis B with liver stagnation and spleen deficiency type, are fol owed by the damp heat type, liver kidney yin deficiency, spleen kidney yang deficiency, blood stasis type. And liver stagnation and spleen deficiency type, damp heat type, liver kidney yin deficiency, spleen kidney yang deficiency type are of mainly stage S2 fibrosis, blood stasis blocking col ateral type in fibrosis stage S4; 212 cases of mild chronic hepatitis B patients with liver qi stagnation and spleen deficiency, damp heat group relatively flat and vitrinite in fibrosis≥S2 have differences, with statistical significance. [Conclusion] Pathology and TCM syndrome type distribution in liver tissue of patients with chronic hepatitis B have some regularity; TCM syndrome type has correlation with the pathologic change of liver tissue objective.