MORPHOMETRY AND PATHOLOGY OF THE PARASPINOUS MUSCLES IN IDIOPATHIC SCOLIOSIS |
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| Authors: | Ursula T Slager John D Hsu |
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| Institution: | Associate Professor, Pathology (Neuropathology), University of Southern California School of Medicine and Pathologist, Rancho Los Amigos Medical Center, 7705 Golondrinas Avenue, Downey, CA 90242.;Clinical Professor, Orthopedics, University of Southern California School of Medicine and Attending Orthopedic Surgeon and Consultant in Muscle Diseases, Rancho Los Amigos Medical Center. |
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| Abstract: | Muscle biopsies from the apex of both sides of the curve of 31 patients with idiopathic scoliosis showed abnormalities in fiber-type distribution in 68 per cent and in fiber size in 55 per cent. There was no preference for either side. Type 1 fiber predominance was as common as type 1 fiber deficiency. Atrophy occurred in 33 per cent and affected mainly type 1 fibers: atrophy of type 2 fibers was rare. Hypertrophy was limited to type 2 fibers, and occurred in 26 per cent. The strength factor for type 1 fibers exceeded that for type 2. Type 2A fibers were no larger than 2B fibers: there was a large type 2A predominance, more so on the convex side. Most of the muscle changes appear to be secondary and compensatory: none suggests a pathogenesis for the curve. |
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