基于PET探讨自发性高血压大鼠肝阳上亢证模型脑功能变化*

目的利用正电子发射计算机断层显像（positron emission computed tomography，PET）技术，探究自发性高血压大鼠（spontaneously hypertensive rats，SHRs）肝阳上亢证脑功能成像的改变。方法 取8只SHRs作为模型组，10只正常清洁级SD大鼠作为对照组。模型组给予附子汤灌服28 d造模后，将两组大鼠分别进行氟18脱氧葡萄糖（18F-FDG）PET脑功能成像扫描，应用SPM2图像分析软件对两组数据进行双样本t检验，得到SHRs肝阳上亢证脑内葡萄糖代谢变化的区域。结果 与对照组相比，模型组葡萄糖代谢减低脑区有右侧间脑、中脑顶盖、丘脑、基底核、两侧大脑半球、尾状核、纹状体、屏状核、尾状核(P<0.05)；而葡萄糖代谢增高的脑区有右侧大脑半球、联合纤维、胼胝体(P<0.05)。结论 PET可以直观显示自发性高血压肝阳上亢证功能改变的特定脑区，为临床早期诊断，防治高血压导致的认知功能障碍提供了可靠依据。

Changes of Brain Functional Imaging in Spontaneously Hypertensive Rats with Hyperactivity of Liver Yang Based on PET

Objective To explore the changes of brain functional imaging of hyperactivity of liver yang in spontaneously hypertensive rats (SHRs) by positron emission computed tomography (PET). Methods 8 SHRs were taken as model group and 10 normal SD rats as control group. The rats in the model group were administrated with Fuzi decoction for 28 d, then the brain functional imaging of 18F-FDG PET was carried out respectively, and the data of the two groups were tested with SPM2 image analysis software to obtain the areas of glucose metabolism in the brain of SHRs with hyperactivity of liver yang. Results Compared with control group, there were decreased glucose metabolism observed in right diencephalon, midbrain tectum, thalamus, basal nucleus, bilateral cerebral hemispheres, caudate nucleus, striatum, screen nucleus and caudate nucleus (P<0.05), while increased in left cerebral hemispheres, combined fibers and corpus callosum in model group(P<0.05). Conclusion PET can directly display the specific brain areas of the functional change of the spontaneous hypertension with hyperactivity of liver yang, which provides a reliable basis for early clinical diagnosis and prevention of cognitive dysfunction caused by hypertension.