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| 阿立哌唑对首发精神分裂症患者体内IL-6、IL-12的影响 | |
| 引用本文： | 舒莉萍,翁剑驰,李亚飞. 阿立哌唑对首发精神分裂症患者体内IL-6、IL-12的影响[J]. 现代中西医结合杂志, 2009, 18(28): 3404-3405 |
| 作者姓名： | 舒莉萍 翁剑驰 李亚飞 |
| 作者单位： | 1. 贵阳医学院,贵州,贵阳,550004 2. 贵州航空工业集团300医院,贵州,贵阳,550006 3. 贵州省第二人民医院,贵州,贵阳,550004 |
| 基金项目： | 贵阳医学院院青年基金资助项目 |
| 摘 要： | 目的观察首发Ⅰ型、Ⅱ型精神分裂症患者经阿立哌唑治疗前后血浆中白细胞介素(IL)-6、IL-12水平的变化。方法选择35例首发精神分裂症患者作为患者组,经阿立哌唑规范治疗8周后,采用ELISA法检测治疗前后患者血浆中IL-6、IL-12的含量;同时选择18例健康志愿者作为对照组。结果患者组治疗前后血浆IL-6、IL-12水平均明显低于对照组;治疗后血浆IL-12水平高于治疗前。结论精神分裂症患者存在IL-6、IL-12介导的免疫功能紊乱。 |
| 关 键 词： | 精神分裂症 阿立哌唑 IL-6 IL-12 |
Effect of aripiprazole on IL-6 and IL-12 in patients with first-episode schizophrenics |
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| Shu Liping,Weng Jianchi,Li Yafei. Effect of aripiprazole on IL-6 and IL-12 in patients with first-episode schizophrenics[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2009, 18(28): 3404-3405 | |
| Authors: | Shu Liping Weng Jianchi Li Yafei |
| Abstract: | Objective It is to observe the changes of concentration of IL-6 and IL-12 in plasma of first-episode typeⅠandⅡschizophrenics patients before and after treatment with aripiprazole.Methods 35 cases of patients with first-episode schizophrenics were chosen as patient group,and the concentration of IL-6,IL-12 in plasma in the group were determined by ELISA methods after 8 weeks' treatment with aripiprazole.At the same time,18 healthy volunteers were chosen as control group.Results The levels of IL-6 and IL-12 in plasma in patient group before and after treatment were obviously lower than that in control group.The level of plasma IL-12 was significantly higher after treatment than that before treatment in patient group.Conclusion There is immune dysfunction induced by IL-6 and IL-12 in patients with schizophrenia. |
| Keywords: | IL-6 IL-12 |
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