| 黄芪三七合剂质量标准研究 |
| |
| 引用本文： | 张仕瑾,兰杨,王娅俐,赵茂林,郭廷东,张燕,唐志立,谢席胜. 黄芪三七合剂质量标准研究[J]. 中国药业, 2021, 0(6): 58-61 |
| |
| 作者姓名： | 张仕瑾 兰杨 王娅俐 赵茂林 郭廷东 张燕 唐志立 谢席胜 |
| |
| 作者单位： | 川北医学院第二临床医学院·四川省南充市中心医院药学部·个体化药物治疗南充市重点实验室;川北医学院医学影像学院;川北医学院第二临床医学院·四川省南充市中心医院肾内科 |
| |
| 基金项目： | 四川省科技厅科技计划项目[21ZDYF2053];四川省教育厅科研计划项目[18ZB0223];四川省中医药管理局中医药科研专项[2018QN026,2018YY007];四川省南充市哲学社会科学重点研究基地项目[YAZX19-Z-04,YAZX19-Y-02];四川省南充市市校合作科研专项[NSMC20170109,18SXHZ0453];川北医学院科研发展计划项目[CBY18-A-YB32]。 |
| |
| 摘 要： | 目的 建立黄芪三七合剂的质量标准.方法 采用薄层色谱法对制剂中黄芪、三七、当归进行定性鉴别;采用高效液相色谱法测定人参皂苷Rg1含量,色谱柱为Shimadzu C18柱(150 mm×4.6 mm,5μm),流动相为乙腈-水(19:81,V/V),流速为1.0 mL/min,检测波长为203 nm,柱温为35℃,进样量...
|
| 关 键 词： | 黄芪三七合剂 薄层色谱法 高效液相色谱法 人参皂苷Rg1 质量标准 |
Quality Standard of Huangqi Sanqi Mixture |
| |
| ZHANG Shijin,LAN Yang,WANG Yali,ZHAO Maolin,GUO Tingdong,ZHANG Yan,TANG Zhili,XIE Xisheng. Quality Standard of Huangqi Sanqi Mixture[J]. China Pharmaceuticals, 2021, 0(6): 58-61 |
| |
| Authors: | ZHANG Shijin LAN Yang WANG Yali ZHAO Maolin GUO Tingdong ZHANG Yan TANG Zhili XIE Xisheng |
| |
| Affiliation: | (The Second Clinical Medical College of North Sichuan Medical College·Department of Pharmacy,Nanchong Central Hospital·Nanchong Key Laboratory of Individualized Drug Therapy,Sichuan,China 637700;School of Medical Imaging,North Sichuan Medical College,Nanchang,Sichuan,China637000;The Second Clinical Medical College of North Sichuan Medical College·Department of Nephrology,Nanchong Central Hospital,Nanchang,Sichuan,China637000) |
| |
| Abstract: | Objective To establish the quality standard of Huangqi Sanqi Mixture.Methods Thin-layer chromatography(TLC)was adopted for the qualitative identification of Astragali Radix,Notoginseng Radix et Rhizoma and Angelicae Sinensis Radix.High-performance liquid chromatography(HPLC)was adopted for the content determination of ginsenoside Rg1,the chromatographic column was Shimadzu C18 column(150 mm×4.6 mm,5μm),the mobile phase was acetonitrile-water(19∶81,V/V),the flow rate was 1.0 m L/min,the detection wavelength was 203 nm,the column temperature was 35℃,and the injection volume was 10μL.Results The TLC chromatograms of Astragali Radix,Notoginseng Radix et Rhizoma and Angelicae Sinensis Radix had clear spots and no negative interference.The linear range of ginsenoside Rg1 was 0.178-0.890μg/m L.The RSDs of precision,stability and repeatability tests were less than 2.0%.The average recovery of ginsenoside Rg1 was 99.30%with RSD of 1.10%(n=6).Conclusion The established qualitative and quantitative methods are specific,simple and reproducible,which can be used for the quality control of Huangqi Sanqi Mixture. |
| |
| Keywords: | Huangqi Sanqi Mixture TLC HPLC ginsenoside Rg1 quality standard |
| 本文献已被 维普 等数据库收录！ |
|
