| 抗凋零基因Bcl-2产物在食管癌中的表达及意义 |
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| 引用本文： | 田辉,王善政,陈明菊,刘文军,张超. 抗凋零基因Bcl-2产物在食管癌中的表达及意义[J]. 中国综合临床, 1997, 0(6) |
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| 作者姓名： | 田辉 王善政 陈明菊 刘文军 张超 |
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| 作者单位： | 山东医科大学附属医院!250012(田辉，王善政，陈明菊，刘文军)，山东桓台县人民医院(张超) |
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| 摘 要： | 抗凋零基因Bcl－2可抑制细胞凋零，促进细胞增殖，与肿瘤发生密切相关。作者利用免疫组织化学方法观察了63例食管疾组织中Bcl-2基因产物的表达情况，结果发现Bcl-2的阳性表达率为60．3％，明显高于癌旁组织（P＜0．05），其表达与食管癌淋巴结转移显著相关（P＜0．05），且与肿瘤分化程度有关（P＜0．05）。结果提示Bcl－2基因可能参与食管癌的发生发展过程，其表达可作为检测患者预后的参考指标。
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| 关 键 词： | 食管癌 Bcl－2基因 免疫组化 |
EXPRESSION OF BCL-2 PROTEIN IN ESOPHAGEAL CARCINOMA AND ITS CLINICAL IMPLICATIONS |
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| Tian Hui,Zhang Chao, Whng Shanzheng,et al.. EXPRESSION OF BCL-2 PROTEIN IN ESOPHAGEAL CARCINOMA AND ITS CLINICAL IMPLICATIONS[J]. Clinical Medicine of China, 1997, 0(6) |
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| Authors: | Tian Hui Zhang Chao Whng Shanzheng et al. |
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| Abstract: | Bcl-2,one of apoptosis-suppressing genes,can inhibit apoptosis of both some normal and tumor cells,and is related to the development of some tumors. In the present study,the expression of Bcl-2 was examined in 63 cases of esophageal carcinoma by using imunohistochemistry. The results show that 60. 3% of esophageal earcinoma are positive to Bcl-2 antibody- The expression levels of Bcl-2 are associated with clinical stage and grading of the esophageal carcinoma (P<0-.05). It is indicated that the inhibition of apoptosis might be one of the reasons for the development of esophageal carcinoma. |
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| Keywords: | Esophageal carcinoma Apoptosis-suppressing gene Immuno-histochemistry |
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