PIM-1在前列腺癌组织中的表达及其与PSA的关系

目的:探讨PIM-1蛋白在前列腺癌组织中的表达及其与PSA复发之间的关系。方法:利用免疫组化SP检测68例前列腺癌和37例良性前列腺增生(BPH)组织中PIM-1蛋白的表达。结果:在前列腺癌组织中PIM-1蛋白表达的阳性率为67.65%(46/68);BPH组织中40.54%(15/37),两组表达的差异有显著意义(P<0.05)。PIM-1蛋白表达的阳性率在前列腺癌Gleason分级中6分33.33%(7/21),7分75%(21/28),8～10分94.74%(18/19),组间比较差异有显著性(P<0.05)。临床分期中在Ⅰ、Ⅱ、Ⅲ、Ⅳ期PIM-1蛋白表达率分别为47.62%、53.85%、73.33%、94.74%,36个月随访PSA复发状况采用Kaplan-Meier方法分析,PIM-1蛋白表达与有无复发分别是78.26%(36/46)和45.45%(10/22),差异有显著性(P<0.05)。结论:前列腺癌中PIM-1蛋白表达与前列腺癌的Gleason分级、临床分期以及PSA复发有密切关系,提示PIM-1基因在前列腺癌演化和进展中有重要作用,可能是前列腺癌的预后指标。

Expression of PIM-1 in prostate cancer tissue and its relationship with PSA recurrence

Objective: To explore the expression of the PIM-1 protein in prostate cancer tissue and its relationship with PSA recurrence.Methods: We used the immunohistochemical SP method to detect the expression of the PIM-1 protein in the prostate tissues of 68 cases of prostate cancer(PCa) and 37 cases of benign prostatic hyperplasia(BPH).Results: The positive rate of the PIM-1 protein expression was 67.65%(46/68) in the PCa tissue,significantly higher than 40.54%(15/37) in the BPH tissue(P <0.05).Its positive rates in PCa Gleason scores 6,7 and 8-10 were 33.33%(7/21),77.5%(21/28) and 94.74%(18/19),respectively,with significant between-group differences(P<0.05),and those in stages Ⅰ,Ⅱ,Ⅲ and Ⅳ of PCa were 47.62%,53.85%,73.33% and 94.74%,respectively.Kaplan-Meier analysis of the results of a 36-month follow-up showed the ratios of PIM-1 expression to PSA recurrence and non-recurrence were 10/22(45.45%) and 36/46(78.26%),respectively,with statistically significant differences(P <0.05).Conclusion: PIM-1 protein expression in PCa tissue is closely related to the Gleason score and clinical stage of PCa and PSA recurrence,which suggests that the PIM-1 gene plays an important role in PCa evolution and progression,and may be an indicator for the prognosis of PCa.