Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters |
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| Authors: | Ye Tian Ming Wei Lijun Wang Yuankai Hong Dan Luo Yinlin Sha |
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| Institution: | 1.Department of Biophysics, Single-Molecule and Nanobiology Laboratory, School of Basic Medical Sciences, Peking University, Beijing 100191, China; (M.W.); (L.W.);2.CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China |
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| Abstract: | Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially for in vivo animal imaging. A gold nanocluster was coupled with dihydrolipoic acid to obtain a functionalized nanoprobe; the material displayed significant features, including a large two-photon absorption cross-section (up to 1.59 × 105 GM) and prolonged fluorescence lifetime (>300 ns). The two-photon and time-resolution techniques were used to perform cell imaging and in vivo imaging. |
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| Keywords: | two-photon imaging time-gated imaging gold nanoclusters in vivo imaging |
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