胸片呈不同表现的支原体肺炎患儿T细胞亚群的变化

目的: 探讨胸片呈不同表现的肺炎支原体肺炎(mycoplasma pneumonia,MPP)患儿的T细胞亚群变化。方法: 选择MPP患儿156例,根据胸片是否呈大叶性肺炎改变分为2组, 其中A组患儿胸片呈大叶性改变;B组患儿胸片呈支气管肺炎或云絮状改变。选择同期体检正常的健康儿童62名作为健康对照组(C组)。检测3组患儿的T细胞亚群并比较分析。结果: A组和B组患儿的CD4+和CD4+/CD8+均较C组明显降低, 而CD8+则显著升高, 其中A组更为显著(P<0.01)。结论: 免疫损伤在MPP的起病机制中有重要作用, 年龄较大的MPP患儿, 胸片表现易呈大叶性肺炎, 且受到的免疫抑制强。

The changes of T cell subsets in Mycoplasma pneumonia children with different chest X-ray manifestations

Objective:To explore the changes of T cell subsets in Mycoplasma pneumonia( MPP) children with different chest X-ray manifestations. Methods:One hundred and fifty-six children with MPP were divided into group A and group B according to the lobar pneumonia change. The chest X-ray in group A and group B showed the lobar pneumonia change and non-lobar pneumonia change, respectively. Sixty-two healthy children were set as the control group(group C). The T cell subsets in 3 groups were detected and analyzed. Results:Compared with group C,the levels of CD4 + and CD4 + /CD8 + in group A were significantly lower,while the level of CD8 + in group A was significantly higher(P<0. 01). Conclusions:Immune injury plays an important role in the pathogenesis of MPP. The chest X-ray in older MPP children shows lobar pneumonia,which is strongly immunodepressed.