镉对机体铜,锌含量的影响

作者研究了螺蛳对镉的生物富集,镉进入生物体后,体内铜水平明显下降。40只成年雌鼠分成5组,1组对照,4组染毒,所有染毒组给以40ppm(以Cd计)氯化镉溶液,其中三组分别再加铜、锌和铁。研究进行了共六个月。结果表明:对照组无异常发现,染毒组出现骨质疏松和皮质变薄,骨中铜水平明显下降。48只成年大鼠分成三组(雌雄各半),A组为对照组,B组喂以采自镉污染区的镉米,C组同样喂镉米再给10ppm(以Cd计)氯化镉溶液。实验共进行了两个月。染毒组骨锌明显下降。上述结果表明,镉所致缺铜或缺锌,在痛痛病发病机理中,可能是一个重要的因素。

THE INFLUENCE OF CADMIUM ON THE CONTENTS OF COPPER AND ZINC IN ORGANISMS

This paper reported the results of 3 experiments. The first was a studyon the bioconcentration of cadmium by snails (Bellamya Aeruginosa (Reeve)).As cadmium entered the body of snails, the body Cu content decreasedobviously. In the second experiment, 40 adult rats were fed with the watersolution of cadmium (Cd 40 mg/L) for 6 months. The results showed thatno change was observed in the control group, but in the experimental groupthere was osteoporosis with thinned cortex, and bone Cu level decreasedsignificantly. In the third experiment 48 adult rats were fed with the ricecontaminated with cadmium for two months. The results showed that thebone Zn content declined significantly. It suggest that the Cu and/or Zndeficiencies caused by the excess of cadmium may be an important factorin development of Itai-Itai disease.