| 不同药物对绝经后骨质疏松症短期疗效观察 |
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| 引用本文： | 张新玉,魏丽. 不同药物对绝经后骨质疏松症短期疗效观察[J]. 新疆医科大学学报, 2011, 34(5): 524-528 |
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| 作者姓名： | 张新玉 魏丽 |
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| 作者单位： | 新疆医科大学第一附属医院风湿科,新疆,乌鲁木齐,830011 |
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| 基金项目： | 民政部老年学和老年医学"十一五"研究计划老年骨质疏松研究基金 |
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| 摘 要： | 目的观察阿仑膦酸钠维D3片、鲑鱼降钙素注射剂及鼻喷剂治疗绝经后骨质疏松的疗效,比较3者缓解腰背痛的效果。方法将117例患者随机分为阿仑膦酸钠维D3片(A组)、鲑鱼降钙素注射剂(B组)、鲑鱼降钙素鼻喷剂(C组),6个月后评价3组骨密度、1,25双羟维生素D3和血清骨钙素与治疗前的变化,比较治疗后3组在提升骨密度和降低骨钙素有无差异,并在治疗4、7、10、14、30 d比较3组缓解腰背痛的变化。结果治疗6个月后,3组腰椎、股骨颈和髋部骨密度均较治疗前明显增加(P<0.05),6个月后3组骨密度比较无明显差异(P>0.05);3组1,25-双羟维生素D3均较治疗前明显升高(P<0.05),血清骨钙素较治疗前明显下降(P<0.05);治疗7d后,鲑鱼降钙素注射剂组在缓解腰背疼痛上效果明显优于阿仑膦酸钠维D3片组(P<0.05),治疗10 d后,鲑鱼降钙素注射剂组和鼻喷剂组缓解腰背疼痛效果均明显优于阿仑膦酸钠维D3片组(P<0.05),30 d后3组在缓解腰背痛上效果相当(P>0.05)。结论阿仑膦酸钠维D3片、鲑鱼降钙素注射剂和鼻喷剂治疗绝经后骨质疏松的疗效均较显著,半年内3者疗效相当,鲑鱼降钙素在缓解腰背痛上效果优于阿仑膦酸钠维D3片。
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| 关 键 词： | 绝经后骨质疏松 药物 骨密度 疼痛 |
The short-term effect observation of different medicilles in treating postmenopausal osteoporosis |
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| ZHANG Xin-yu,WEI Li. The short-term effect observation of different medicilles in treating postmenopausal osteoporosis[J]. Journal of Xinjiang Medical University, 2011, 34(5): 524-528 |
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| Authors: | ZHANG Xin-yu WEI Li |
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| Affiliation: | ZHANG Xin-yu,WEI Li(Department of Rheumatology,First Affiliated Hospital,Xinjiang Medical University,Urumqi 830011,China) |
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| Abstract: | Objective To observe the short-term effectiveness of alendronate sodium vitamin D-3 tablets,salcatonin injection and salcatonin nasal spray in treating postmenopausal osteoporosis and to compare the effect of these medicines in relieving backpain.Methods The 117 patients were divided into three groups randomly,alendronate sodium vitamin D-3 tablets group(group A),catonin injection group(group B) and salcatonin nasal spray group(group C).To evaluate the difference between before and after 6 months of treatme... |
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| Keywords: | postmenopausal osteoporosis medicine bone density pain |
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