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| 通窍活血汤对血管性痴呆大鼠脑皮质中NO、ET-1、LPO含量的实验研究 | |
| 引用本文： | 葛朝亮,汪宁. 通窍活血汤对血管性痴呆大鼠脑皮质中NO、ET-1、LPO含量的实验研究[J]. 安徽医药, 2011, 15(9): 1063-1065 |
| 作者姓名： | 葛朝亮 汪宁 |
| 作者单位： | 安徽医科大学第一附属医院,安徽,合肥,230022;安徽中医学院,安徽省中药研究与开发重点实验室,安徽,合肥,230038 |
| 基金项目： | 安徽省优秀青年科技基金，康缘中医药科技创新基金项目 |
| 摘 要： | 目的观察通窍活血汤(TQHXD)对血管性痴呆大鼠脑皮质中一氧化氮(NO)、内皮素-1(ET-1)、脂褐素(LPO)含量的影响,明确通窍活血汤对血管性痴呆大鼠的疗效。方法通过酶联免疫吸附试验(ELISA)方法测定大鼠脑皮质中NO、ET-1、LPO的浓度。结果模型对照组较假手术组相比,VD大鼠脑皮质中NO、ET-1、LPO的含量显著提高(P<0.05);通窍活血汤高、中剂量组能明显降低VD大鼠脑皮质NO、ET-1、LPO的含量(P<0.05)。结论 TQHXD具有明显降低VD大鼠的脑皮质中氧自由基的作用。 |
| 关 键 词： | 通窍活血汤 血管性痴呆大鼠 一氧化氮 内皮素-1 脂褐素 |
Content changes of NO,ET-1,LPO in cerebral cortex of vascular dementia in rats on TQHXD |
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| GE Chao-liang,WANG Ning. Content changes of NO,ET-1,LPO in cerebral cortex of vascular dementia in rats on TQHXD[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(9): 1063-1065 | |
| Authors: | GE Chao-liang WANG Ning |
| Affiliation: | 1.The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China;2.Anhui Traditional Chinese Medicine College,Anhui Provincial Key Laboratory of Chinese Medicine Research and Development,Hefei,Anhui 230038,China) |
| Abstract: | Aim To study the content changes of NO,ET-1,LPO in cerebral cortex of vascular dementia in rats on TQHXD,and to clearly indicate the efficacy of TQHXD on vascular dementia in rats.Methods NO,ET-1,LPO in rat＇s cerebral cortex were evaluated by enzyme-linked immunosorbent assay.Results Compared with sham-operated group,the content of No,ET-1,LPO obviously increased（P0.05）.In high dose group and middle dose group,TQHXD could significantly decrease the content of NO,ET-1,LPO in cerebral cortex of vascular dementia rats（P0.05）.Conclusion TQHXD could decrease the role of oxygen free radicals in the cerebral cortex in VD rats. |
| Keywords: | Tongqiao Huoxue Decoction vascular dementia rats NO ET-1 LPO |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |