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基因印记与胚胎发育
引用本文:尹丽君,黄荷凤. 基因印记与胚胎发育[J]. 浙江大学学报(医学版), 2007, 36(5): 509-514
作者姓名:尹丽君  黄荷凤
作者单位:浙江大学医学院,附属妇产科医院,浙江,杭州,310006
基金项目:国家重点基础研究发展计划(973计划)
摘    要:
基因印记的擦除、建立和维持是正常胚胎发育的基础,这一过程的实现主要有赖于各种DNA甲基转移酶的准确表达和密切合作,多种遗传综合征和胚胎发育缺陷与基因印记异常有关。基因印记对原始生殖细胞胞核全能性、配子成熟、胚胎生长发育、胎盘结构和功能,以及出生后个体的生长发育均有重要意义。

关 键 词:基因印记  DNA甲基化  胚胎发育  DNA修饰甲基酶类  综合征  基因
文章编号:1008-9292(2007)05-0509-06
修稿时间:2007-06-06

Genetic imprinting and embryonic development
YIN Li-jun,HUANG He-feng. Genetic imprinting and embryonic development[J]. Journal of Zhejiang University. Medical sciences, 2007, 36(5): 509-514
Authors:YIN Li-jun  HUANG He-feng
Affiliation:The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
Abstract:
Erasure,establishment and maintenance of genetic imprinting are indispensable for normal embryonic development.All these processes depend on accurate expression and intimate cooperation of kinds of DNA methyltransferases.Many genetic syndromes and embryo developmental anomalies are caused by abnormality of genetic imprinting.Genetic imprinting is important for the nucleus totipotential of primordial germ cell,maturation of gamete,growth and development of emboryo,structure and function of placenta as well as postnatal growth and development of individuals.
Keywords:Genetic imprinting  DNA Methylation  Embryonic development  DNA Modification methylases  Syndrome  Genes
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