PSORIASIS-LIKE LESIONS IN GUINEA PIGS RECEIVING PROPRANOLOL |
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| Authors: | BINNUR TÜ ZÜ N,M.D.,,YALÇ IN TÜ ZÜ N,M.D.,,NURAY GÜ REL,M.Sc,. ,NÜ KHET TÜ ZÜ NER,M.D.,,TUNCAY ALTUG,Ph,.D. ,SEVIM BÜ YÜ KDEVRIM,M.D. |
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| Affiliation: | From the University of Istanbul, Experimental Medicine Research and Application Center (DETAM) and Cerrahpasa Medical Faculty, Istanbul, Turkey. |
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| Abstract: | ![]()
Background. β-Blockers cause a psoriasiform eruption. We investigated the skin effects of systemic propranolol in a formal protocol. Methods. Propranolol, 0.1 mg/day, was used systemically by gavage in eight albino guinea pigs. Normal saline was given to another group of seven guinea pigs. Results. Propranolol produced psoriasiform lesions in five of seven guinea pigs on the 30th day. Biopsies showed acanthosis, parakeratosis, microabscesses, and cellular infiltration of upper dermis. Topical application of propranolol did not produce clinical psoriasiform changes, while acanthosis and papillomatosis was observed in six of the six guinea pigs. Conclusions. Systemically given propranolol can lead to psoriasis-like lesions, which might be due to a serum factor. |
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