碟脉灵注射液对麻醉犬器官血流及血管阻力的影响

目的:研究碟脉灵注射液（DMLI）对麻醉犬器官血流及血管阻力的影响。方法:20只杂种犬随机分为4组：5%葡萄糖对照组、脉络宁注射液组、DMLI 4和8 mL•kg^-1组。应用MF-27型电磁流量计分别测定用药前和用药后不同时间脑血流量(CBF)和脑血管阻力(CVR)，外周血流量(PBF)和外周血管阻力(PVR)及其血压（SBP、DBP）和心率（HR）等指标。结果：DMLI 4和8 mL•kg^-1于给药180 min内均能明显增加CBF，并明显降低CVR，其作用优于脉络宁注射液，DMLI亦能增加PBF，并降低PVR，其作用不如脉络宁注射液。除给药后60 min可使HR明显减慢外，其余各时间点均无明显改变，但能明显降低DBP，而对SBP无明显影响。结论：DMLI对实验性脑缺血的保护作用可能与其明显改善脑循环，增加脑组织血液供应有关。

Effects of Diemailing injection on organ blood flow and vascular resistance in anesthetized dogs

Objective To elucidate the effects of Diemailing injection (DMLI) on organ blood flow and vascular resistance in anesthetized dogs. Methods Cerebral blood flow,cerebral vascular resistance,peripheral blood flow,peripheral vascular resistance,blood pressure, and heart rate (HR) were measured using the MF 27 electromagnetic flowmeter. Results DMLI(4 and 8 mL·kg -1 iv drip) increased cerebral blood flow and decreased cerebrovascular resistance within 180 min,its effect was more obvious than Mailuoning injection (MLNI).DMLI also elevated peripheral blood flow and lowered peripheral vascular resistance,its effect was less than MLNI.HR was slowed down only at 60 min whereas at other time not.DMLI obviously reduced diastolic pressure but exerted no effect on systolic pressure. Conclusion Protective effect of DMLI on experimental cerebral ischemia may be related to improving cerebral circulation and increasing cerebral blood supplyment.