雷洛昔芬对绝经后妇女同型半胱氨酸及血脂的影响

目的观察雷洛昔芬(RLX)对绝经后妇女同型半胱氨酸及血脂的影响。方法采用随机、双盲、安慰剂对照研究,对62例绝经后妇女分为试验组(n=32)和安慰剂组(n=30),分别给予RLX 60 mg/d及安慰剂,共12个月。结果RLX组用药6个月前后同型半胱氨酸无明显变化,用药12个月时明显降低,与安慰剂组比较有显著性差异(P<0.05);RLX组用药12个月总胆固醇、低密度脂蛋白胆固醇显著降低(P<0.01),高密度脂蛋白胆固醇和甘油三酯则无明显变化。结论RLX可降低绝经后妇女同型半胱氨酸水平,降低血清总胆固醇、低密度脂蛋白胆固醇水平。

Effects of raloxifene on homocysteine and serum lipids in postmenopausal women

Objective: To observe the effects of raloxifene(RLX) on homocysteine and serum lipids in postmenopausal women.Method: Sixty-two postmenopausal women were randomized to receive either RLX 60 mg(n=32) daily or placebo(n=30) daily for 12 months. H(e) and serum lipids were determined before the treatment and 12 months after the treatment.H(e) was also determined after 6-month drug administration.Results: Compared with the placebo control,the women treated with RLX showed no difference of H(e) after 6 months of treatment,but a significant decrease of H(e) was found after 12 months of treatment(P<0.05).Total cholesterol(TC) and lower-density lipoprotein cholesterol(LDL-C) in RLX treated women exhibited lower values than those in the placebo women(P<0.01).No difference was found for high-density lipoprotein cholesterol(HDLC) or triglyceride levels between the two groups.Conclusion: RLX decreased H(e) and TC,LDL-C levels in postmenopausal women.