颅内多发性动脉瘤患者术前破裂责任动脉瘤的判断

目的 探讨多发性颅内动脉瘤患者诊疗过程中误判破裂责任动脉瘤的原因和解决方法.方法 对2003-2009年上海市浦东新区浦南医院收治的25例颅内多发性动脉瘤致自发性蛛网膜下腔出血(SAH)患者的临床资料进行回顾分析,术前根据Nehls等报道的评判原则诊断破裂责任动脉瘤,被确定破裂的责任动脉瘤均在48 h内完成夹闭手术治疗.不能通过一次手术入路夹闭治疗的多发动脉瘤则远期进一步手术治疗.结果 25例患者均通过手术证实破裂动脉瘤的确切部位,其中术中确认的责任破裂动脉瘤与术前诊断一致者20例(80%);而术前判断错误者4例(16%),且术后均发生再出血,其中2例因再出血死亡;还有1例诊断不明确.结论 约80%左右的责任动脉瘤可通过术前CT、脑血管造影检查明确诊断,有疑议时应增加检查手段,如CTA或MRI等;术中需对责任动脉瘤进行确认;即使已经发现了责任动脉瘤,也要对其他部位的动脉瘤进行术中确认.

Abstract：

Objective To discuss the reasons of false judgments of localization of the rupture aneurysms and find the way to fix this problem in patients with multiple intracranial aneurysms. Methods The clinical data of 25 consecutive patients, who presented with their first spontaneous subarachnoid hemorrhage and had multiple intracranial aneurysms from 2003 to 2009 in our hospital, were analyzed retrospectively. The rupture aneurysms were determined according to Nehls' method that reported before, and the supposed responsible rupture aneurysms w0ere clipped within 48 hours after hemorrhage in all patients. More aneurysms that could not be accessed in the same surgical session were surgically terated later. Results The location of the rupture aneurysm was verified at the time of surgery in all 25 patients. The concordance rate of the prediction and the reality of the rupture aneurysm was 80% (20/25). Four patients ( 16% ) ,in whom the ruptured aneurysm was not correctly identified,rebled after surgery,and 2 patients died as a result of the rebleeding One patients had no clear diagnosis at the end. Conclusion In the reported cases, about 80% rupture aneurysms could be correctly diagnosed before treatment according to the CT and DSA examinations. If clear diagnosis couldn't be made,additional examinations should be considered, such as CTA or MRI. Rupture aneurysms must be confirmed during the operation and the other aneurysms should be checked to exclude additional responsible aneurysms in all cases.

Determination of the localization of rupture aneurysms in patients with multiple cerebral aneurysms and spontaneous subarachnoid hemorrhage

Objective To discuss the reasons of false judgments of localization of the rupture aneurysms and find the way to fix this problem in patients with multiple intracranial aneurysms. Methods The clinical data of 25 consecutive patients, who presented with their first spontaneous subarachnoid hemorrhage and had multiple intracranial aneurysms from 2003 to 2009 in our hospital, were analyzed retrospectively. The rupture aneurysms were determined according to Nehls' method that reported before, and the supposed responsible rupture aneurysms w0ere clipped within 48 hours after hemorrhage in all patients. More aneurysms that could not be accessed in the same surgical session were surgically terated later. Results The location of the rupture aneurysm was verified at the time of surgery in all 25 patients. The concordance rate of the prediction and the reality of the rupture aneurysm was 80% (20/25). Four patients ( 16% ) ,in whom the ruptured aneurysm was not correctly identified,rebled after surgery,and 2 patients died as a result of the rebleeding One patients had no clear diagnosis at the end. Conclusion In the reported cases, about 80% rupture aneurysms could be correctly diagnosed before treatment according to the CT and DSA examinations. If clear diagnosis couldn't be made,additional examinations should be considered, such as CTA or MRI. Rupture aneurysms must be confirmed during the operation and the other aneurysms should be checked to exclude additional responsible aneurysms in all cases.