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| 抗生素89—07的局部刺激性试验 | |
| 引用本文： | 沈伽弟 郑德琪. 抗生素89—07的局部刺激性试验[J]. 中国抗生素杂志, 1997, 22(4): 304-306 |
| 作者姓名： | 沈伽弟 郑德琪 |
| 作者单位： | 军事医学科学院毒物药物研究所 |
| 摘 要： | 用新西兰大白兔比较了抗生素８９－０７和阿米卡星（ＡＭＫ）肌肉注射的肌肉刺激性。１００ｍｇ受试药物（按碱基计算）溶于１．０ｍｌ生理盐水中，１次注入一侧股四头肌。给药２４和９６ｈ，根据肉眼观察和病理组织学检查结果，判断局部肌肉损伤程度。本试验结果证明，肌注抗生素８９－０７引起的肌肉损伤程度比ＡＭＫ轻。 |
| 关 键 词： | 刺激性 局部 肌肉 抗生素89－07 |
Local irritation study on antibiotic 89 07 |
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| Shen Jiadi,Zheng Deqi,shen Juying,Qu Wensheng and Li Peizhong. Local irritation study on antibiotic 89 07[J]. Chinese Journal of Antibiotics, 1997, 22(4): 304-306 | |
| Authors: | Shen Jiadi Zheng Deqi shen Juying Qu Wensheng Li Peizhong |
| Abstract: | The muscle irritation caused by antibiotic 89 07 was compared with that of amikacin (AMK) in adult NZW rabbits. A single dosage of 100mg drugs dissovled in 1.0 ml saline solutions were injected into the quadriceps femoris respectively. The degree of local muscular injury at the time of 24 and 96 hours after the injection was evaluated according to the result of gross local observation and histopathological observation. The result of present experiment shows that the degree of muscular injury caused by antibiotic 89 07 was milder than amikacin. |
| Keywords: | Irritation Local Muscle Antibiotic 89 07 |
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