86株铜绿假单胞菌的耐药特征分析

［目的］研究铜绿假单胞菌的耐药特征．［方法］采用美国临床实验室标准化委员会推荐的纸片 扩散法和 ＤＡＤＥ 公司的 Ｍｉｃｒｏ－Ｓｃａｎ仪器测定了对 ３年来初次分离的 ８６株铜绿假单胞菌对 ２０种抗生素 的耐药特征．［结果］铜绿假单胞菌对氨噻酸单胺菌素、氧哌嗪青霉素－他唑巴坦、氨苄青霉素－青霉烷 砜、甲氧苄氨嘧啶－磺胺甲基异■唑、硫酸丁胺卡那霉素、丙氟哌酸、头孢塔齐定、亚胺硫霉素的敏感率最 高，分别为８１．６％，９１．１％，８３．０％，８８．２％，９２．０％，８９．１％，６８．２％，９４．３％．而对氨苄青霉素、头孢唑 啉、噻吩甲氧头孢菌素、博拿霉素、头孢三嗪、呋肟头孢菌素、头孢噻吩、氧哌嗪青霉素高水平耐药，敏感 率为１０．９％～９．３％．［结论］氨苄青霉素－青霉烷砜、氨曲南、氧哌嗪青霉素－三唑巴坦、增效磺胺甲基异 ■唑、硫酸丁胺卡那霉素、丙氟哌酸、亚胺硫霉素对所分析的铜绿假单胞菌有较高的活性，是治疗铜绿假 单胞菌感染的最有效的抗生素

Investigation of antimicrobial resistant characteristics for 86 pseudomonas aeruginosa isolates

OBJECTIVE To investigate the antimicrobial resistant patterns of Psendomonas aeruginosa. METHODS Using the Disc diffusion method (NCCLS) and the instrument of Micro-Scan of America, it was detected that the antimicrobial resistant characteristics for 86 pseudomonas aeruginosa isolates that was against for 20 antibiotics in the past 3 years. RESULTS Among 20 antibiotics, the Aztreonam (81 .6 % ) , Piperacillinum-Tazp (91. 1 % ), Sultamicillin (83 .0% ), Sulfamethoxazol (88 .2% ), Amikacin (92 % ) , Ciprofloxacin(89. 1 % ), Ceftazidime (68 .2% ), Imipenem (94. 3 % ) had the highest susceptible rates. The pseudomonas derugmosa was highly resistant to the Ampicillin, Cefazolin, Cefoxitin, Bleomycin, Ceftriaxon, Cefuroxime, Cephalothin, Piperacillin. The susceptible rates were between 10. 9 % - 9. 3 %. CONCLUSION The Sultamicillin, Aztreonam, Piperacillinum-Tazp, Sulfamethoxazol, Amikacin, Ciprofloxacin, Imipenem are the most effective antibiotics against the pseudomonas aeruginosa and the most ideal antinlicrobial agents for serious pseudomonas aeruginosa bacteremia.