Depletion of Beta Cell Intranuclear Rodlets in Human Type II Diabetes |
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| Authors: | Yi Yuan Zhou Soufiane El Hallani Fady Balaa Waleed Mohammad Douglas A. Gray John Woulfe |
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| Affiliation: | 1.Department of Pathology,Case Western Reserve University,Cleveland,USA;2.Department of Pathology,Stanford University,Palo Alto,USA;3.Department of Surgery,The Ottawa Hospital,Ottawa,Canada;4.Department of Surgery,Jaber Al-Ahmed Armed Forces Hospital,Kuwait City,Kuwait;5.Department of Biochemistry, The Ottawa Hospital Research Institute, Microbiology and Immunology,University of Ottawa,Ottawa,Canada;6.Department of Pathology and Laboratory Medicine, Ottawa Hospital Research Institute, Centre for Neurosciences,University of Ottawa,Ottawa,Canada |
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| Abstract: | Intranuclear rodlets (INRs) are rod-shaped intranuclear bodies of unknown function present in the nuclei of pancreatic beta cells. Previous studies have demonstrated a significant depletion of INRs from beta cells in mouse models of type II diabetes, suggesting that they may have pathological significance. The objective of the present study was to determine whether beta cell INRs show quantitative alterations in human type II diabetes. In sections of non-neoplastic pancreas from 23 diabetic patients and 23 controls who had undergone complete or partial pancreatectomy, we detected a significant reduction in the proportion of INRs in insulin-immunoreactive beta cells. In addition, we showed that beta cell INRs are immunoreactive for the RNA-binding protein HuR. The results of this study confirm and extend our previous study and implicate this enigmatic nuclear structure in the cellular pathophysiological mechanisms underlying the development of type II diabetes in humans. |
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