The relationship of p53 Protein and lymph node metastases in invasive breast cancer |
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| Authors: | Masakuni Noguchi Hirohisa Kitagawa Kazuo Kinoshita Michael Thomas Itsuo Miyazaki Yashuo Saito Yuji Mizukami Akitaka Nonomura Takatoshi Michigishi Shinobu Nakamura |
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| Affiliation: | (1) The Operation Center, Kanazawa University Hospital, School of Medicine, Takara-machi, 13-1, 920 Kanazawa, Japan;(2) Department of Surgery II, Kanazawa University Hospital, School of Medicine, Takara-machi, 13-1, 920 Kanazawa, Japan;(3) Department of Surger, Kanazawa University Hospital, School of Medicine, Takara-machi, 13-1, 920 Kanazawa, Japan;(4) Department of Pathology, Kanazawa University Hospital, School of Medicine, Takara-machi, 13-1, 920 Kanazawa, Japan;(5) Department of Nuclear Medicine, Kanazawa University Hospital, School of Medicine, Takara-machi, 13-1, 920 Kanazawa, Japan;(6) Deparment of Medicine III, Kanazawa University Hospital, School of Medicine, Takara-machi, 13-1, 920 Kanazawa, Japan |
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| Abstract: | ![]()
The p53 expression in invasive breast cancers from 106 patients was correlated with clinicopathological variables to ascertain its usefulness for estimating prognosis. The p53 expression was significantly associated with the number of axillary lymph node metastases and the presence of internal mammary lymph node metastases; however, it was not associated with age, menopausal status, histologic type, or tumor size. Although p53 expression was a significant prognostic factor according to univariate analysis, it did not appear to be an independent prognostic factor according to multivariate analysis. Thus, the prognostic power of p53 expression is likely to be weak and therefore probably of limited clinical value. Nevertheless, the number of patients in our study was small, and we believe that an investigation of a larger series of patients is indicated. |
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| Keywords: | p53 protein breast cancer lymph node metastasis |
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