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| 氟对大鼠肾脏细胞凋亡的影响 | |
| 引用本文： | 夏涛, 余日安, 冉鹏, 王爱国, 陈学敏. 氟对大鼠肾脏细胞凋亡的影响[J]. 中国公共卫生, 2002, 18(8): 897-898. DOI: 10.11847/zgggws2002-18-08-01 |
| 作者姓名： | 夏涛 余日安 冉鹏 王爱国 陈学敏 |
| 作者单位： | 1.华中科技大学同济医学院环境卫生学教研室 武汉430030 |
| 基金项目： | "九五"国家医学科技攻关项目(No.96-906-04-02) |
| 摘 要： | 目的 探讨氟对肾脏细胞凋亡的影响.方法 给wistar大鼠饮用含50mg/L氟化钠的高氟水,6个月后,用TUNEL法和流式细胞术检测大鼠肾脏细胞凋亡.结果 氟能诱导大鼠肾脏TUNEL阳性细胞,而且凋亡细胞率较对照组明显增高.结论 研究提示氟可诱导大鼠肾脏细胞凋亡. |
| 关 键 词： | 氟 细胞凋亡 肾脏细胞 |
| 文章编号： | 1001-0580(2002)08-0897-02 |
| 收稿时间： | 2001-05-06 |
| 修稿时间： | 2001-05-06 |
Study of Fluoride on Kidney Cell Apoptosis in Rat |
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| XIA Tao, YU Ri-an, RAN Peng, . Study of Fluoride on Kidney Cell Apoptosis in Rat[J]. Chinese Journal of Public Health, 2002, 18(8): 897-898. DOI: 10.11847/zgggws2002-18-08-01 | |
| Authors: | XIA Tao YU Ri-an RAN Peng |
| Affiliation: | 1.Department of Environmental Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China |
| Abstract: | Objective To study effects of fluride on apoptosis of kidney cells of rats.Methods Wistar rats were provided with distilled water containing NaF(50mg/L)for six months.Kidney cell apoptosis were detected by TUNEL(TdT-mediated dUTP Nick End Labelling)and flow cytometry.Results TUNEL-positive cells could be detected in fluoride-treated rat kidney,the apoptotic rates of fluoride-treated kidney cells were higher than those of the control significantly.Conclusions This result indicated that fluoride could induce kidney cells apoptosis of rats. |
| Keywords: | fluoride apoptosis |
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