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| 液相色谱-串联质谱法研究白花前胡甲素脂质体在大鼠体内的药动学 | |
| 引用本文： | 王秀敏,李丽萍,连惠龙,张真,邹军,朱铉. 液相色谱-串联质谱法研究白花前胡甲素脂质体在大鼠体内的药动学[J]. 中国新药与临床杂志, 2011, 0(5) |
| 作者姓名： | 王秀敏 李丽萍 连惠龙 张真 邹军 朱铉 |
| 作者单位： | 厦门大学医学院药学系; |
| 基金项目： | 福建省科技计划重点项目(2010Y0053); 厦门市科技计划项目(3502Z20103009) |
| 摘 要： | 目的制备白花前胡甲素脂质体并进一步研究其在大鼠体内的药动学。方法采用乙醇注入法制备白花前胡甲素脂质体,采用正交设计优化处方。白花前胡甲素脂质体按5、10、20mg·kg~(-1)低、中、高3个剂量经大鼠颈静脉给药后检测一定时间点的血药浓度,对照组为10mg·kg~(-1)的白花前胡甲素溶液。结果制备的脂质体含药量为2g·L~(-1),包封率为93.2%,脂质体高、中、低剂量组及对照组的t_(1/2)分别为(136.58±22.86),(74.12±6.97),(44.93±7.47),(51.26±5.13)min;AUC_(0-∞)分别为(215.93±33.24),(91.75±26.47),(29.22±4.47),(66.90±14.54)min·mg·L~(-1)。结论成功制备了白花前胡甲素脂质体,制得的白花前胡甲素脂质体在大鼠体内半衰期显著延长,生物利用度有明显的提高。 |
| 关 键 词： | 白花前胡 大鼠 脂质体 药动学 |
Pharmacokinetics of dl-praeruptorin A liposomes in rats by LC-MS/MS method |
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| WANG Xiu-min,LI Li-ping,LIAN Hui-long,ZHANG Zhen,ZOU Jun,ZHU Xuan. Pharmacokinetics of dl-praeruptorin A liposomes in rats by LC-MS/MS method[J]. Chinese Journal of New Drugs and Clinical Remedies, 2011, 0(5) | |
| Authors: | WANG Xiu-min LI Li-ping LIAN Hui-long ZHANG Zhen ZOU Jun ZHU Xuan |
| Affiliation: | WANG Xiu-min,LI Li-ping,LIAN Hui-long,ZHANG Zhen,ZOU Jun,ZHU Xuan (Department of Pharmacy,Medical College of Xiamen University,Xiamen FUJIAN 361005,China) |
| Abstract: | AIM To study the pharmacokinetics of dl-praeruptorin A liposomes in rats by LC-MS/MS method.METHODS dl-Praeruptorin A liposomes was obtained by the ethanol injection method.Pharmacokinetic parameters were determined after intravenous administration of dl-praeruptorin A liposomes(5,10 and 20 mg·kg~(-1)) and dl-praeruptorin A solution(control solution,10 mg·kg~(-1)) in rats.RESULTS The drug content was 2 g·L~(-1),encapsulation efficiency was 93.2%.The t_(1/2) of dl-praeruptorin A liposomes(5,10 and 20 mg·kg~(-1)) and control solution were(136.58±22.86),(74.12±6.97),(44.93±7.47),(51.26±5.13) min,AUC_(0-∞) were (215.93±33.24),(91.75±26.47),(29.22±4.47),(66.90±14.54) min·mg·L~(-1) respectively. CONCLUSION dl-praeruptorin A liposomes can increase the bioavailability and has a long half-life in rats. |
| Keywords: | dl-praeruptorin A rats liposomes pharmacokinetics |
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