| 米非司酮治疗后MMP-9和TIMP-1在异位和在位子宫内膜中的表达 |
| |
| 引用本文： | 蔡蕾,袁卿,龙雯晴,喇端端.米非司酮治疗后MMP-9和TIMP-1在异位和在位子宫内膜中的表达[J].上海交通大学学报(医学版),2007,27(8):981-983. |
| |
| 作者姓名： | 蔡蕾 袁卿 龙雯晴 喇端端 |
| |
| 作者单位： | 上海交通大学医学院瑞金医院妇产科 上海200025(蔡蕾，龙雯晴，喇端端)，同济大学第一妇婴保健院 上海200040(袁卿) |
| |
| 摘 要： | 目的探讨米非司酮治疗子宫腺肌症的机制是否与其纠正了基质金属蛋白酶-9(MMP-9)和组织金属蛋白酶抑制物-1(TIMP-1)在异位内膜的表达失衡有关。方法35例行全子宫切除术的子宫腺肌症患者分为米非司酮治疗组(n=19)和对照组(n=16)。子宫内膜作为在位内膜标本,腺肌瘤作为异位内膜标本,采用免疫组化法测定并比较在位和异位内膜中MMP-9和TIMP-1水平。结果米非司酮治疗组异位内膜组织中,MMP-9在腺上皮细胞内的表达显著低于对照组(P<0.05),TIMP-1的表达显著高于对照组(P<0.05),MMP-9/TIMP-1的比值显著低于对照组(P<0.05)。结论子宫腺肌症患者经过米非司酮治疗后,异位内膜中MMP-9表达下降,TIMP-1表达上升;米非司酮通过下调MMP-9/TIMP-1的比值来控制异位内膜组织的种植侵袭。
|
| 关 键 词： | 子宫腺肌症 子宫内膜 基质金属蛋白酶 组织金属蛋白酶抑制剂 米非司酮 |
| 文章编号： | 0258-5898（2007）08-0981-03 |
| 修稿时间： | 2006-10-26 |
Expression of MMP-9 and TIMP-1 in ectopic and eutopic endometrium of adenomyosis treated with mifepristone |
| |
| CAI Lei,YUAN Qing,LONG Wen-qing,LA Duan-duan.Expression of MMP-9 and TIMP-1 in ectopic and eutopic endometrium of adenomyosis treated with mifepristone[J].Journal of Shanghai Jiaotong University:Medical Science,2007,27(8):981-983. |
| |
| Authors: | CAI Lei YUAN Qing LONG Wen-qing LA Duan-duan |
| |
| Institution: | 1. Department of Obstetrics and Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China; 2. Shanghai First Maternity Infant Hospital, Tongji University, Shanghai 200040, China |
| |
| Abstract: | Objective To study whether the mechanism of mifepristone in treating adenomyosis is suppressing matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1(MMP-9/TIMP-1). Methods Thirty-five patients in the mifepristone treated group(19 cases of adenomyosis) and the control group(16 cases of adenomyosis,non-drug treated) underwent hysterectomy.Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium.Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Results The ectopic endometrium of the mifepristone treated group expressed lower level of MMP-9,higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group(P<0.05). Conclusion In patients with adenomyosis treated with mifepristone,MMP-9 expression decreases and TIMP-1 expression increases.Mifepristone could reduce the ratio of MMP-9/TIMP-1 to prevent the evolution of adenomyosis. |
| |
| Keywords: | adenomyosis endometrium matrix metalloproteinases tissue inhibitors of metalloproteinases mifepristone |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
