| （E）—3—[3—烷氧基—4—（芳烯酰基）氧基]苯丙烯酸酯的合成 |
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| 引用本文： | 刘鹰翔,计志忠.（E）—3—[3—烷氧基—4—（芳烯酰基）氧基]苯丙烯酸酯的合成[J].广东药学院学报,1998,14(2):81-83,85. |
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| 作者姓名： | 刘鹰翔 计志忠 |
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| 作者单位： | [1]广东药学院药物化学教研室 [2]沈阳药科大学合成药物研究室 |
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| 摘 要： | 报道了以肉桂酸（１）为起始原料，经混酐化、酰化、Ｄｏｅｂｎｅｒ等三步反应制得关键中间体３－［３－甲氧基－４－（３－苯丙烯酰基）氧基］苯基丙烯酸（４）。其与对甲基苯磺酰氯形成混酐或在ＤＣＣ和ＤＭＡＰ系统催化下分别与苯甲醇、肉桂醇、２－萘酚、对羟基苯乙酸反应成酯。所合成的标题化合物均经元素分析、红外光谱和核磁共振氢谱确证结构与构型。
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| 关 键 词： | 苯丙烯酸酯 合成 肉桂醇 苯甲醇 |
Synthesis of (E) 3[3 Alkoxy 4 (3 Arylpropenoyl)Oxy] Phenylpropenoic Acid Ester |
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| Liu Yingxiang,Ma Yuzhuo,Ji Zhizhong.Synthesis of (E) 3[3 Alkoxy 4 (3 Arylpropenoyl)Oxy] Phenylpropenoic Acid Ester[J].Academic Journal of Guangdong College of Pharmacy,1998,14(2):81-83,85. |
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| Authors: | Liu Yingxiang Ma Yuzhuo Ji Zhizhong |
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| Institution: | Liu Yingxiang,Ma Yuzhuo,Ji Zhizhong 1 |
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| Abstract: | With cinnamic acid as the starting material,the intermediate 3 3 methoxy 4 (3 phenylpropenoyl)oxy]phenylpropenoic acid was prepared by means of three steps reaction of mixanhydridisation ,acylation and Doebner condensation The esterification of the compound was obtained through the reactions with benzyl alcohol,cinnamic alcohol,2 naphthol and 4 hydroxyphenylacetic acid respectively The chemical structures and the conformations of the title ester compounds were confirmed by means of elementary analysis, IR and 1H NMR spectrometry |
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| Keywords: | phenylpropenoic acid ester synthesis structure determination |
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