冠心病伴代谢综合征患者冠状动脉病变特点及与相关危险因子相关性的分析

目的探讨冠心病（CHD）伴代谢综合征（Ms）患者冠状动脉病变特点及与相关危险因子肿瘤坏死因子α（TNF—q）和高敏C反应蛋白（hs—CRP）]的相关性。方法检测211例CHD患者空腹血糖（FBG）、餐后2h血糖（2hPBG）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL-C）、TNF-α、hs-CRP，并常规检查体重指数、腹围、血压。其中135例CHD患者行冠状动脉造影检查，根据病变损害程度评分。结果211例CHD患者中有76例（36％）伴MS，其冠状动脉病变分数高于不伴MS者。FBG、2hPBG、TC、TG、LDL—C、HDL—C、血压、TNF—α、hs—CRP水平增高与冠状动脉造影病变分数相关。伴MS者TNF-α、hs—CRP水平增高者多于不伴MS者。结论CHD伴MS患者的冠状动脉病变严重程度高于不伴MS患者，且多数伴MS患者的TNF—α、hs—CRP水平增高。MS可作为预测冠状动脉狭窄严重程度的指标之一。

Studies on the angicgraphical characteristics of coronary heart disease accompanied with metabolic syndrome and analysis of the correlation with related risk factors

Objective To study the angiographical characteristics of the patients with coronary heart disease （CHD） complicating metabolic syndrome（MS） ,and the correlation with risk factors tumor necrosis factor-or（TNF-α） and high sensitive C reactive protein （hs-CRP） ]. Methods The levels of fasting blood glucose （ FBG）, 2 hours postprandial blood glucose （ 2hPBG）, triglyceride （ TG）, cholesterol （ TC ）, high-density lipoprotein cholesterol （ HDL-C）, low density lipoprotein cholesterol （ LDL-C）, TNF-α, hs-CRP in CHD patients were measured. Body weigh index and blood pressure were measured by routine technique. Coronary arterial stenosis of 135 CHD patients were measured by the image manipulation system of angiography. The relationship between MS and coronary stenosis severity in CHD was analysed. Results The incidence of CHD patients accompanied with MS was 36% , multi factor anova analysis showed that there was a positive correlation between the levels of FBG, 2hPBG, TG, TC, LDL-C, TNF-α, hs-CRP, blood pressure and the grade of coronary arteritenosis severity. The grade of coronary arteristenosis severity in CHD patients with MS was higher than in CHD patients without MS. TNF-α and hs-CRP levels in CHD patients with MS were higher than those in CHD without MS. Conclusions The grade of coronary arteristenosis severity in CHD patients complicating MS was higher than in CHD patients not complicating MS. than it may be one of the predictor of severity of coronary arterial stenosis in CHD. TNF-α and hs-CRP levels were higher in CHD patients than those in CHD patients without MS.