诺维本与顺铂治疗非小细胞肺癌

To evaluate the effect by “standard/chem otherapy with navelbine (NVB) plus cisplatin (PDD) in the treatment of nonsm all cell lung cancer (NSCLC). ”Methods There were 40 NSCLC patients in this study. 38 were male and 2 female. The median age of the patients was 52 years old. Squam ous carcinom a was the most conmon type of malignancy (36 cases).Sixteen patients were inthe stage Ⅲ a and 20 patients in stage Ⅲb-Ⅳ Twenty patients had no prior chemotherapy and 20 received previous chemotherapy. Results Complete response was observed in 4 patients and partial response in 15 patients. The overall response rate was 47.5 %. The response rate of the primary chemothera-py was 60%. The secondary chemotherapy was 35%. The main toxity of NVB was neutropenia which was seen in all treated cases (80.5 % in Grade Ⅱ and Ⅲ) The local venous toxity was observed in 35 % of the patients. Conclusion The so-called standard chemotherapy with NVB plus PDD in the treatment of NSCLC may obtain a higher response rate and lower toxity. It is effective especially for the patients of in an earlier stage.