肝癌组织中survivin、VEGF的表达及意义

目的探讨survivin与血管内皮生长因子（VEGF）在肝细胞肝癌（HCC）组织中的表达及其临床意义。方法采用免疫组化法检测50例HCC组织和20例正常肝组织中survivin、VEGF蛋白的表达,并分析其与HCC临床病理参数的关系。结果50例HCC组织中survivin、VEGF蛋白的阳性表达率分别为64.0%、68.0%,在正常肝组织中的表达率分别为0、10%,两者相比,P均〈0.05;survivin、VEGF蛋白表达与HCC临床分期及淋巴结转移相关（P〈0.05）;HCC中survivin、VEGF蛋白表达呈正相关（r=0.886,P〈0.05）。结论survivin和VEGF蛋白在HCC中表达率较高,为肝癌的分子靶向治疗提供了新的靶点;survivin和VEGF在HCC中的表达关系密切,对肝癌的发展可能有协同作用;测定HCC中survivin、VEGF蛋白的表达,对判断患者预后及指导治疗有较大帮助。

Expression and significance of survivin and VEGF in hepatocellular carcinoma and significance

Objective To discuss the expression of survivin and VEGF in hepatocellular carcinoma and their relationship and their clinical significance. Methods The expression of survivin and VEGF in hepatoeellular carcinoma were studled by immunohistochemical technique with their relation to follow-up data, analyzed their detect outcome with clinical path- ologic character. Results The 32 of 50 hepatocellular carcinoma specimens （64.0%） were positive for survivin, The 34 of 50 hepatocellular carcinoma specimens （68.0%） were positive for VEGF. The expression of survivin were not found in normal hepatic tissue;the 2 of 20 hepatocellular carcinoma specimens （ 10% ） were positive for VEGF. The expression of survivin and VEGF are significant difference between hepatocellular carcinoma and normal hepatic tissue. Their expression was related to clinical stage and lymph node metastasis of hepatocellular carcinoma patients （ P 〈 0.05 ）. There was a close correlation between the expression of survivin and VEGF in hepatocellular carcinoma, proved by the correlation test （ r = 0. 886 ,P 〈 0.05 ）. Conclusions survivin and VEGF are over-expressed in HCC tissues, and provide a theoretical basis for application of molecular targeted drugs, survivin expression combinated with VEGF expression maybe have synergistic effect to HCC progression. Determin the expression of survivin and VEGF in HCC tissues can help the prognosis with judgement patients and guide treatment.