| 微电泳赛庚啶对丘脑束旁核伤害性单位放电的影响 |
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| 引用本文： | 佟振清,陈水村.微电泳赛庚啶对丘脑束旁核伤害性单位放电的影响[J].南方医科大学学报,1989,9(4):316-318. |
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| 作者姓名： | 佟振清 陈水村 |
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| 作者单位： | 第一军医大学生理学教研室
(佟振清)，第一军医大学生理学教研室(陈水村) |
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| 摘 要： | 微电泳导入5-HT拮抗剂赛庚啶(Cyproheptadine,Cyp)至丘脑束旁核(Pf),观察Cyp对Pf伤害性神经元放电的影响.结果表明,Cyp能增加Pf伤害性神经元的自发和诱发放电。提示Cyp能阻断内源性5-HT对Pf伤害性神经元自发和诱发放电的抑制作用.
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| 关 键 词： | 束旁核 伤害性单位 赛庚啶 微电泳 5-羟色胺 |
Effect of microiontophoretically applied cyproheptadine on the nociceptive unit discharge in the nucleus parafascicularis of thalamus |
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| Tong Zhenqing,Chen Shuicun.Effect of microiontophoretically applied cyproheptadine on the nociceptive unit discharge in the nucleus parafascicularis of thalamus[J].Journal of Southern Medical University,1989,9(4):316-318. |
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| Authors: | Tong Zhenqing Chen Shuicun |
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| Institution: | Department of Physiology |
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| Abstract: | Experiments were performed on 25 rats. Putative serotonergic antagonist, Cy-proheptadine ( Cyp) , was applied microiontophoretically on the nucleus parafas-cicularis of the thalamus ( Pf) and the effect of Cyp on Pf nociceptive neuronal discharge was observed. The result suggested that Cyp can increase the spontaneous and evoked discharge rates of Pf nociceptive neuron, and that Cyp may antagonize inhibitory effect of endogenous serotonin on the spontaneous and evoked discharges of Pf nociceptive neurons. |
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| Keywords: | cyproheptadine serotonin nucleus parafascicularis nociceptive neuron microiontophoresis |
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