实验性血管性痴呆大鼠模型的实时步态行为分析研究

目的：建立实验性血管性痴呆大鼠模型，研究其实时步态行为。方法采用双侧颈总动脉结扎方法建立大鼠血管性痴呆模型，术后50 d进行实时步态行为训练与测试，记录步行速度、步行周期、步幅、步基、支撑时长、摆动时长等指标共计96项。结果与假手术组比较，实验性血管性痴呆模型组大鼠有19项步态指标出现了显著地统计学差异，模型动物步态行为异常主要体现在前肢步宽增加（P ＜0．05），各足步行周期延长（P ＜0．05），各足支撑时长增加（P ＜0．05，P ＜0．01），摆动时长缩短（P ＜0．05），同源协调性降低（P ＜0．05），各足足迹平均面积和平均强度增加（P ＜0．05，P ＜0．01）。结论实验性血管性痴呆大鼠模型实时步态行为异常与临床患者所见症状相似，可为该模型的建立和判断提供借鉴。

Experimental vascular dementia rats model of real-time gait behavior analysis

Objective To establish experimental vascular dementia rat model and evaluate gait behavior. Methods Vascular dementia rat model induced by bilateral carotid artery ligation methods, 50 days for real-time gait behavioral training and testing after surgery. Results Compared with the sham group, Experimental vascular dementia model rats had 19 gait indicators appeared significantly statistical difference, Animal model gait abnormal behavior is mainly reflected in the forelimb step width increased (P < 0.05), each foot walk cycle extension (P < 0.05), Each foot stance time increased (P < 0.05, P < 0.01), and the swing time shortened (P < 0.05), Homologous coupling shortened (P < 0.05), each foot average footprint area and average intensity increased (P < 0.05, P < 0.01). Conclusion Experimental rat model of vascular dementia in real time gait abnormal behavior and seen in patients with clinical symptoms similar, can provide a reference model for the establishment and judgment.