| 乳糖微粉研磨改性降低白芷提取物吸湿性的工艺筛选及机制探究 |
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| 引用本文： | 张芳,韩丽,张定堃,杨迎光,唐宜轩,伍振峰,杨明.乳糖微粉研磨改性降低白芷提取物吸湿性的工艺筛选及机制探究[J].中国实验方剂学杂志,2015,21(3):6-9. |
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| 作者姓名： | 张芳 韩丽 张定堃 杨迎光 唐宜轩 伍振峰 杨明 |
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| 作者单位： | 成都中医药大学 药学院, 成都 611137;成都中医药大学 药学院, 成都 611137;成都中医药大学 药学院, 成都 611137;成都中医药大学 药学院, 成都 611137;成都中医药大学 药学院, 成都 611137;成都中医药大学 药学院, 成都 611137;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004;成都中医药大学 药学院, 成都 611137;江西中医药大学 现代中药制剂教育部重点实验室, 南昌 330004 |
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| 基金项目： | 国家自然科学基金面上项目(81274098) |
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| 摘 要： | 目的:筛选乳糖微粉研磨改性降低白芷提取物吸湿性的工艺条件,分析乳糖微粉的抗吸湿机制。方法:以吸湿率为评价指标,采用单因素试验考察乳糖种类、药辅比、研磨时间对乳糖微粉研磨改性以降低白芷提取物吸湿性的工艺条件,通过粒径分布、微观结构等物理指标对改性物加以佐证。结果:乳糖微粉研磨改性最佳工艺条件为白芷提取物与乳糖超微粉(粉碎1 min)等比例研磨3 min。改性物的粒径d0.1,d0.5,d0.9分别为3.477,15.078,54.501μm,接触角(7.7±0.66)度,乳糖颗粒包覆在白芷提取物表面。结论:乳糖适度微粉化能明显降低白芷提取物的吸湿初速度与吸湿加速度的绝对值,能显著降低白芷提取物的吸湿性。抗吸湿作用可能与研磨改性使得乳糖粒子附于白芷提取物表面密切相关。
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| 关 键 词： | 白芷提取物 乳糖微粉 研磨改性 吸湿性 接触角 粒径分布 |
| 收稿时间： | 2014/5/12 0:00:00 |
Process Screening and Mechanism Analysis of Lactose Micropowder Grinding Modification to Decrease Hygroscopicity of Angelicae Dahuricae Radix Extract |
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| ZHANG Fang,HAN Li,ZHANG Ding-kun,YANG Ying-guang,TANG Yi-xuan,WU Zhen-feng and YANG Ming.Process Screening and Mechanism Analysis of Lactose Micropowder Grinding Modification to Decrease Hygroscopicity of Angelicae Dahuricae Radix Extract[J].China Journal of Experimental Traditional Medical Formulae,2015,21(3):6-9. |
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| Authors: | ZHANG Fang HAN Li ZHANG Ding-kun YANG Ying-guang TANG Yi-xuan WU Zhen-feng and YANG Ming |
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| Institution: | College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM), Chengdu 611137, China;Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China |
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| Abstract: | |
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| Keywords: | Angelicae Dahuricae Radix extract lactose micropowder grinding modification hygroscopicity contact angle particle size distribution |
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